缓症链球菌肺炎的药物敏感试验分析

Sensitivity Analysis of 189 Cases of Streptococcus Mitis Pneumonia

目的调查近年缓症链球菌肺炎抗菌素敏感性和耐药性情况,以指导抗菌药物的合理应用。方法采用回顾性调查方法,对2009年9月至2012年2月189例0~14岁痰培养阳性缓症链球菌肺炎患儿的药物敏感试验结果进行分析。结果 189份痰培养报告中,缓症链球菌对药物敏感性依次为万古霉素、亚胺培南、环丙沙星、头孢吡肟、左氧氟沙星、奈替米星、氨曲南;耐药性依次为克林霉素、阿奇霉素、青霉素G、苯唑西林、氨苄西林/舒巴坦、庆大霉素;对头孢曲松和哌拉西林/他唑巴坦的耐药率分别为44.4%、45.5%。结论缓症链球菌肺炎经验用药首选氨曲南或头孢曲松或哌拉西林/他唑巴坦,根据痰培养药敏试验结果选用抗生素具有重要临床指导意义。

Objective To survey the antibiotics sensitivity and resistance of the streptococcus mitis pneumon in recent years to guide the rational use of antimicrobial agents.Methods The data of the antibiotics sensitivity in 189 patients with the streptococcus mitis pneumonia in the age of 0 to 14 years from September of 2009 to February of 2012 were retrospectively studied,which sputum culture all were positive.Results In the189 copies of sputum culture,the antibiotics sensitivity to Streptococcus mitis was by turns： vancomycin,imipenem,ciprofloxacin,cefepime,levofloxacin,netilmicin,aztreonam;the drug resistance to streptococcus mitis was by turns： clindamycin,azithromycin,benzylpenicillin,ampicillin/sulbactam,gentamicin.The rates of the drug resistance to ceftriaxone and piperacillin/tazobactam were 44.4% and 45.5% respectively.Conclusion The Experience of drug use for the streptococcus mitis pneumonia preferred ceftriaxone and piperacillin/tazobactam and gentamicin;according to sputum culture,drug susceptibility test results has important clinical significance to guide the use of antimicrobial agents.