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p73基因的研究进展 被引量:1

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摘要 p73基因是p53家族的一个新成员 ,在结构和功能上与p53基因具有相似性。p73基因定位于1p3 6.3 3 ,具有四种转录剪切变异体 ,无肿瘤特异性的突变。p73基因过度表达时可激活特定的靶基因而抑制细胞生长和诱导凋亡。p73基因的转录激活作用受到许多因素影响。本文综述了p73基因功能与调控研究的最新进展。
出处 《国外医学(生理病理科学与临床分册)》 2000年第4期261-262,共2页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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  • 1力超,郑天荣,张红,陆丽俐,蔡晓雯.肝细胞癌中PTEN、p73蛋白表达及临床意义[J].中国肿瘤,2005,14(11):760-762. 被引量:1
  • 2Zwahlen D, Tschan M P,Grob T J, et al. Differential expression of P73 splice variants and protein in bengin and malignant ovarian tumours [J]. Int J Cancer, 2000,88 (1) : 66-70.
  • 3Niyazi M,Ghazizadeh M,Konishi H, et al. Expression of P73 and c-Abl proteins in human ovarian carcino- mas[J]. Nippon Med Sch,2003,70(3):234-242.
  • 4Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to P53 at lp36, a region frequently deleted in neuroblastoma and other human cancers[J]. Cell, 1997,90(2):809-819.
  • 5Scaruffi P,Casciano J, et al. Lack of expression in ma ture B-ALL and identification of three new spicing va- riants restricted to pre B and C-ALL indicate a role of P73 in B cell ALL differentiation[J]. Leukemia, 2000, 14(3) : 518-525.
  • 6De Laurenzi V, Costanzo A, Barearoli D, et al. Two new P73 splice variants, gamma and delta, with different transcriptional activity[J]. J Exp Med, 1998, 188 ( 9 ) : 1763-1768.
  • 7Kang M J, Park B J, Byun D S, et al. Loss of omprint- ing and elevated expression of wild-type P73 in human gastric adenocarcinoma[J]. Clin Cancer Res, 2000,6: 1767-1771.
  • 8Yokozaki H, Shitara Y, Fujimoto J Y, et al. Alterations of P73 preferentially occur in gastric adenocarcinomaswith foveolar epithelial phenotype[J]. Int J Cancer, 1999,83(2) : 192-196.
  • 9Zai Ka AI, Kovalev S, Marchenko N D, et al. Overex- pression of the wild type P73 gene in breast cancer tis-sues and cell lines[J]. Cancer Res, 1999,59( 13 ) :3257- 3263.
  • 10Zai Ka A I,Slade N,Erster S H,et al. NP73,a domi- nant-negative inhibitor of wild-type P53 and TAP73, is up-regulated in human tumors [ J ]. J Exp Med,2002,196(6):765-780.

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