蛋白酪氨酸磷酸酶相互作用蛋白51的研究进展

Research progress on protein tyrosine phosphatase interacting protein 51

蛋白酪氨酸磷酸酶相互作用蛋白(PTPIP)51是一种进化保守的蛋白质,在人类和多种哺乳动物中具有同源性。PTPIP51蛋白表达十分广泛,在不同的组织可有不同的相对分子质量;在不同组织中可与相应的细胞因子结合,具有不同的功能;与多种受体复合物结合,触发和启动多种信号通路的级联反应,参与细胞的代谢、增殖和分化以及功能活动、程序性死亡和迁移等过程。本文就PTPIP51的生物学特性、表达及其调节、信号配体和生理功能以及与肿瘤的关系等研究进展作一综述。

The protein tyrosine phosphatase interacting protein 51 （PTPIP51） was a conserved protein whose amino acid sequence of human was found sequence homology with several other mammalian species. The expression profile of PTPIP51 protein were widely found in human and there were several different calculated molecular masses of the protein in a tissue-specific manner. The protein interacted with different signaling partners piaying variety functions in human tissues. Int6racting with its receptor complexes, signaling cascades of different pathways were activated and promoted mediating cells proliferation, differentiation, apoptosis and motility. In this paper, we will review the biological characteristics, and gene expression, regulation; signal ligands and the physiological ,functions and relationship with human tumors of PTPIP51.