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β受体的调节与相关疾病研究进展 被引量：2

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摘要 β受体分布广泛 ,介导一系列重要的生理和生化效应。一方面与其激动剂结合产生信息传递物质 ,引起生物效应 ,另一方面受体本身又受激动剂体内自身活性物质生理及病理因素的调节。其功能异常与许多疾病如心衰、动脉硬化、高血压等密切相关 ,其中偶联及脱敏机制近年来已成为研究疾病病因的热点。
作者 任京力 赵树进
机构地区 中山医科大学药理教研室 中国人民解放军广州军区总医院
出处 《解放军药学学报》 CAS 2000年第4期203-205,共3页 Pharmaceutical Journal of Chinese People's Liberation Army
关键词 Β肾上腺素受体 分型 偶联 脱敏
分类号 R969 [医药卫生—药理学]
  • 相关文献

参考文献20

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二级参考文献3

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共引文献5

同被引文献22

  • 1刘红岩,从玉文,陈波,善亚君,杨振,赵振虎,毛秉智.Mpl相互作用蛋白RACK1的筛选与鉴定[J].军事医学科学院院刊,2005,29(3):204-207. 被引量：2
  • 2Hellgren I, Sylven C, Magnusson Y. Study of betal-adrenergic receptor expression in human tissues: immunological approach[J]. Biol Pharm Bull, 2000,23:700-703.
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  • 5Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease[J]. Trends Biochem Sci, 2003, 28: 671-678.
  • 6Zhu WZ, Wang SQ, Chakir K, et al. Linkage of betal-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase Ⅱ[J]. J Clin Invest, 2003, 111:617-625.
  • 7Wegener AD, Simmerman HK, Lindemann JP, et al. Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation[J].J Biol Chem, 1989, 264: 11468-11474.
  • 8Zhu WZ, Zheng M, Koch WJ, et al. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes[J]. Proc Natl Acad Sci USA, 2001, 98: 1607.
  • 9Prabhu SD, Wang G, Luo J, et al. Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium[J]. J Mol Cell Cardiol, 2003, 35: 483-493.
  • 10Bae S, Xiao Y, Li G, et al. Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart[J]. Am J Physiol Heart Circ Physiol, 2003, 285: H983-H990.

引证文献2

解放军药学学报
2000年 第4期

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