恶性肿瘤患者输注血小板临床效果分析

Retrospective analysis of effectiveness of apheresis platelets transfusion in patients with malignant tumor

目的:探讨恶性肿瘤患者输注血小板的疗效及影响因素。方法:收集505例恶性肿瘤患者939例次血小板输注前后,外周血小板计数,出血改善情况;输血次数;疾病类型及治疗方式。结果:单纯血小板降低者输注血小板后能提高外周血小板数,改善出血,有效率达84%,随输注次数增加有效率降低为79%,但脾大、感染、发热、凝血功能障碍等因素影响输注效果(P<0.01)。疾病类型及治疗方式等也影响血小板输注效果,血小板减少病例中因化疗药物导致血小板减少占86%,血液病占13%,放疗导致血小板减少只占0.005%。结论:输注血小板能有效地治疗恶性肿瘤患者因疾病或化疗、放疗导致的血小板减少症,很多因素影响血小板输注。

Objective：To explore the efficacy and influencing factors of platelet transfusion in patients with malignant tumor.Method：The effects of platelet transfusion indications,before and after infusion of platelets,peripheral platelet count,number of transfusions,skin,mucous membrane,the improvement of organ hemorrhage were collected and analyzed.Result：After platelet infusion,the peripheral platelet count of those who simply platelet decreased could be improved and the bleeding were improved.While splenomegaly,infection,fever,coagulation dysfunction,infusion number,type of disease and treatment methods could affect platelet transfusion results.Conclusion：Platelet infusion could effectively treat cancer patients＇ thrombocytopenia induced by chemotherapy and radiotherapy,and many factors would affect platelet transfusion,therefore,platelet transfusion should be individualized.