大叶茜草中环肽类成分的研究

Cyclopeptides from Rubia schumanniana

目的:对大叶茜草Rubia schumanniana根茎中环肽类化合物进行分离和鉴定。方法:大叶茜草根茎的70%甲醇回流提取物经硅胶,RP-18,Sephadex LH-20和HPLC等色谱技术分离纯化,根据波谱数据鉴定化合物的结构。结果:分离得到9个环肽类化合物,分别鉴定为RA-VII(1),RA-V(2),RA-XII(3),rubiyunnanin C(4),RA-X(5),RY-II(6),RA-I(7),RA-XIII(8),RA-XIII-OMe(9)。结论:9个环肽化合物均为首次从大叶茜草中分离得到。

Objective： To separate and identify cyclopeptides of tubers of Rubia schumanniana. Method： The 70% methanol extracts from tubers of Rubia schumanniana were separated and purified by silica gel, RP-18, Sephedax LH-20 and HPLC. Their structures were identified by spectral analysis. Result： Nine cyclopeptides were separated and identified as RA-Ⅱ（1）, RA-V （2）, RA-Ⅷ （3）, rubiyunnanin C （4）, RA-X （5）, RY-Ⅱ （6）, RA-Ⅰ（7）, RA-XIII （8） and RA-XIII-OMe （9）, respectively. Conclusion： All of nine cyclopeptides were separated from R. schumanniana for the first time.