石油菜化学成分研究

Chemical constituents of Pilea cavaleriei subsp.cavaleriei

目的:对民间药材石油菜的化学成分进行研究。方法:用硅胶、葡聚糖凝胶Sephadex LH-20等手段进行分离纯化,并通过1H,13C-NMR,MS等波谱方法鉴定结构。结果:分离鉴定了17个化合物,其中酚酸类6个,分别为苯甲酸(benzoicacid,1),对羟基苯甲醛(4-hydroxy benzaldehyde,2),香豆酸(coumaric acid,3),原儿茶酸(protocatechuic acid,4),没食子酸(gal-lic acid,5),对羟基苯甲酸(4-hydroxy benzoic acid,6);含N化合物6个,分别为3-吲哚甲醛(3-indole carboxaldehyde,7),3-吲哚甲酸(3-indole carboxylic acid,8),4-甲基-(1,2,3)-三唑[4-methyl-(1,2,3)-triazole,9],尿嘧啶(uracil,10),菸酰胺(nicotinam-ide,11),(2S,E)-N-[2-羟基-2-(4-羟基苯)乙酯]阿魏酰胺{(2S,E)-N-[2-Hydroxy-2-(4-hydroxyphenyl)ethyl]ferulamide,12};5个其他类成分,(+)-去氢催吐萝芙醇[(+)-dehydrovomifoliol,13],正三十一烷(hentriantane,14),β-谷甾醇(β-sitosterol,15),棕榈酸(palmitic acid,16),胡萝卜苷(daucossterol,17)。结论:所有化合物均为首次从该属植物中分离得到。

Objective： To investigate chemical constituents from folk herb Pilea cavaleriei subsp. cavaleriei. Method： The compounds were separated and purified by silica gel, Sephadex LH-20 and the like. The structures were identified by spectral methods such as 1H, 13C-NMR and MS. Result： Seventeen compounds were isolated and identified as benzoic acid（1）, 4-hydroxy benzaldehyde（2）, coumaric acid（3）, protocatechuic acid（4）, gallic acid（5）, 4-hydroxy benzoic acid（6）, 3-indole carboxaldehyde（7）, 3-indole carbo-xylicacid（8）, 4-methyl-（1,2,3）-triazole（9）, uracil（10）, nicotinamide （11）, （2S,E）-N- ferulamide（12）, （＋）-dehydrovomifoliol（13）,hentriantane（14）, β-sitosterol（15）, palmitic acid（16）, daucossterol（17）, respectively. Conclusion： All compounds were obtained from the genus for the first time.