6590例新生儿先天性甲状腺功能低下筛查分析

Investigation and analysis of congenital hypothyroidism in 6590 neonates

目的对 6 5 90例新生儿于生后 72小时进行先天性甲状腺功能低下的筛查 ,做到早期诊断、早期治疗。方法取足跟血 1～ 2滴于滤纸片上 ,采用酶联免疫方法定量检测血中TSH浓度。以>15mIU/L为阳性可疑病例。结果共筛查新生儿 6 5 90例 ,其中男性婴儿 335 6例 ,女婴 32 34例 ,3例筛查阳性患儿 ,进一步血清检查确诊为甲低患儿 (女婴 2例 ,男婴 1例 ) ,发病率为 1∶2 197。结论甲低的筛查与诊断主要依据实验室检查 。

Objective To screen the congenital hypothyroidism from neonates,so that early stage diagnosis and treatment. Methods The TSH concentration from 6?590 neonates after 72 hours of birth foot blood samples were measured by enzyme linked immunoassay(ELISA).The levels of serum TSH above 15mIU/L as probably positive were regarded. Results 3 patients with the congenital hypothyroidism were identified and the morbidity was 0.46‰.Conclusion The screening and diagnosis of the congenital hypothyroidism were mainly based on laboratory examination.The early screening of thyroid gland function was the crux of early diagnosis.