帕利哌酮缓释片与利培酮治疗精神分裂症的对照研究被引量：3

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摘要目的为了比较帕利哌酮缓释片与利培酮治疗精神分裂症患者的疗效及安全性的差异。方法选取某精神病院60例精神分裂症患者,随机分成帕利哌酮组和利培酮组各30例,分别采用帕利哌酮缓释片和利培酮进行治疗,观察8周。以阳性及阴性症状量表(PANSS)减分率评定疗效,用治疗中出现的症状量表(TESS)评定不良反应,以个人和社会功能量表(PSP)评定社会功能。结果帕利哌酮组与利培酮组的总显效率(痊愈+显效)和总有效率(痊愈+显效+有效)的差异不显著(P>0.05)。患者治疗后,两组的PANSS总分及各因子分明显降低(P<0.05)。与利培酮组比较,帕利哌酮组的不良反应出现频率低、程度轻微,个人和社会功能恢复快。结论帕利哌酮缓释片是一种安全有效的新型抗精神病药,可以明显改善精神分裂症和分裂样精神病患者的精神病性症状及社会功能。

作者敖登格日勒

机构地区内蒙古精神卫生中心

出处《疾病监测与控制》 2012年第8期497-498,共2页 Journal of Diseases Monitor and Control

关键词精神分裂症帕利哌酮缓释片 SCHIZOPHRENIA PALIPERIDONE EXTENDED-RELEASE TABLET

分类号 R749.3 [医药卫生—神经病学与精神病学]

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