2Lipinski, C. Poor aqueous solubility - an industry wide prob- lem in drug discovery. Am Pharm Rev,2002.
3Tang B, Cheng G, Gu JC et al. Development of solid self - e- mulsifying drug delivery systems: preparation techniques and dosage forms [ J ]. Drug Discovery Today,2008.
5AbdaUa, A. Mader,K. Preparation and characterization of a selfemulsifying pellet formulation[J].Eur. J. Pharm. Biopharm, 2907.
6Cole, ET. Challenges and opportunities in the encapsulation of liquid and semi - solid formulations into capsules for oral admin- istration[J]. Adv. Drug. Deliv. Rev. 2008.
9Yi T, Wan JL, Xu HB, et al. A new solid self - microemulsi- fying formulation prepared by spray - drying to improve the oral bioavailability of poorly water soluble drugs[ J ]. European Journal of Pharmaceutics and Biopharmaceutics,2008.
10Fabio C, Elisabetta C. Pharmaceutical composition comprising a water/oil/water double microemulsion incorporated in a solid support [ P ]. WO2003/013421.
8TANG B, CHENG G, GU JC, et al. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms [ J ].Drug Discov Today, 2008,13 ( 13 - 14 ) : 606 - 612.
9Itoh K,Matsui S,Tozuka Y,et al.Improvement of physicochemical properties of N-4472 part Ⅱ:characterization of N-4472 microemulsion and the enhanced oral absorption.International Journal Pharm,2002,246:75-83.
10Park KM,Kim CK.Preparation and evaluation of flurbiprofen-load edmicroemulsion for parenteral delivery[J].Int J Pharm,1999,81:173.