血液透析的慢性肾功能衰竭患者血浆MDA和SOD的变化

The contents of malondialdehyde and superoxide dismutase in the plasma of patients with chronic renal failure by haemodialysis

目的 探讨慢性肾功能衰竭患者血液透析前后的血浆丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量变化的临床意义。方法 用硫代巴比妥法和黄嘌呤氧化酶法测定慢性肾功能衰竭患者血液透析前、后MDA和SOD含量变化。结果 慢性肾功能衰竭患者血液透析后血浆中MDA较血液透析前明显降低 ,而SOD活性则显著升高。结论 血液透析疗法可以减轻自由基对慢性肾功能衰竭患者组织、器官的损伤 ,也预示着应用抗氧化剂可能成为有益的治疗措施之一。

Objective In the interest of clinical significance, the contents of malondialdehyde(MDA) and superoxide dismutase(SOD) in the plasma of patients with chronic renal failure(CRF) by haemodialysis(HD) were investigated. Methods Thiobarbital aicd(TBA) and xanthinoxidase were used as the mensuration for MDA and SOD, respectively, and the contents of MDA and SOD in the plasma of patients with CRF before and after HD were ditermined. Results The content of MDA was decrease obviously, and the activity of SOD was increase significantly in patients with CRF after HD compared with before HD. Conclusions These results show that HD could reduce tissue and organs injury from free radical, and indicate that using antioxidizer may be one of beneficial treatment for CRF.