三维适形放疗联用丹参注射液治疗食管癌临床观察

Clinical effect of salvia miltiorrhiza injection combined with 3D-radiotherapy for esophageal cancer therapy

目的观察丹参注射液同步三维适形放疗（3DCRT）治疗食管癌疗效和不良反应。方法62例食管癌患者随机分为丹参注射液同步放疗组（A组）和顺铂同步放疗组（B组）。均采用加速器6MV的X线3DCRT，总剂量60～70Gy。A组放疗前3d开始静脉滴注丹参注射液20ml／d，至放疗结束；B组放疗同时静脉滴注顺铂30mg／m^2，每周3次，至放疗结束。结果A组的近期有效率为71．0％（22／31），与B组接近[74．2％（23／31）]（X^2=0．522，P〉0．05），多种不良反应发生率降低，A组2、3年生存率分别为66．7％和43.3％，优于B组的55.3％和16．7％（X^2=3．18，X^2=4．526，均P〉0．05）。结论丹参注射液同步3DCRT方案对中晚期食管癌有较好疗效，值得临床推广。

Objective To evaluate the efficacy and toxicity of 3D-radiotherapy combined with salvia mihiorrhiza injection to treat esophageal cancer. Methods 62 patients were randomly divided into group A and B. Group A were treated with 3D-radiotherapy （60-70 Gy） combined with salvia miltiorrhiza injection （20 ml/d）. Group B were treated with 3D-radiotherapy （60-70 Gy） combined with cisplatin （30 mg/m2, dl-d3/w）. Results The 71.0 %（22/31） recent effective rate of group A was obtained[74.2 %（22/31） of group B], the 2 to 3 years survival rates were 66.7 % and 43.3 % respectively （55.3 % and 16.7 % of group B）. Conclusion The effect is good using 3D-radiotherapy combined with salvia miltiorrhiza injection to treat esophageal cancer.