西沙必利对慢性功能性便秘患者结肠转运时间的作用

The effect of cisapride on colonic transit time in patients with chronic functional constipation

目的 了解国人结肠转运时间的正常值 ,并探讨西沙必利对慢性功能性便秘患者的结肠转运时间 (CTT)的作用。方法 通过连续 3d各服一粒含不透X线标志物的胶囊后于第 4、第 7天拍摄腹部平片的简化方法 ,测定 2 5例正常人及 2 5例慢性功能性便秘患者的全结肠及节段结肠转运时间。对全结肠转运时间延长的便秘患者 ,给予西沙必利 10mg每日 3次口服治疗 ,疗程 4周。在最后 1周复查CTT ,比较服药前后CTT的变化。结果 全结肠转运时间的正常值上限为 5 6h ,2 5例便秘患者中 15例的全结肠转运时间延长 ,经西沙必利治疗后平均全结肠转运时间由 10 3.0 7h缩短至 6 6 .80h(P<0 .0 1) ,各节段结肠转运时间亦显著缩短。结论 简化的CTT检查技术简单易行 ,结果可靠。西沙必利能显著缩短慢性功能性便秘患者的全结肠及各节段结肠转运时间 。

Objective To investigate colonic transit time (CTT) in normal subjects and evaluate the effect of cisapride on CTT on chronic functional constipation. Methods Total and segmental CTT were measured in 25 healthy volunteers and 25 patients with chronic functional constipation using radiopaque markers ingested on each of 3 consecutive days with abdominal X rays obtained on the 4th and 7th days. Patients with prolonged total CTT received cisapride 10 mg t.i.d. orally for 4 weeks and CTT was measured again in the last week. Results The maximum normal value of total CTT was 56 h, it was prolonged in 15 of 25 constipated patients. On average the total CTT was significantly shortened from 103.07 h to 66.80 h ( P <0.01), the segmental CTT were also shortened significantly. Conclusion The technique to measure CTT is simple, convenient and reliable. Cisapride, which can reduce total and segmental CTT, is an effective drug in chronic functional constipation.