霉酚酸酯治疗IV型狼疮性肾炎的疗效观察与护理研究

The curative effect observation and nursing of lupus nephritis treated by MMF

目的观察新型免疫抑制剂酶酚酸酯 (MMF)治疗IV型狼疮性肾炎 (LN)的疗效 ,找出其治疗期间的有效护理方法。方法 2 3例经肾活检证实的IV型NL患者 ,均接受传统免疫抑制剂或其它治疗无效或复发 ,改用MMF治疗 ,其中 ,2 1例联合使用小剂量激素 ,MMF剂量 :0 2 5～ 2 0g/d。结果经MMF治疗 12个月后 ,8例肾功能不全者 5例肾功能恢复正常 ,3例需透析者摆脱了透析 ;尿蛋白下降超过基础值 5 0 %者占 10 0 % ;血尿消失率占 2 8 5 %。副作用 :消化道症状 7例 ,占 30 4% ;细菌性肺炎 2例 ,占 8 7% ;带状疱疹 2例 ,占 8 7% ;未见白细胞减少及肝功能异常。结论MMF对IV型LN有独特的疗效 ,其副作用小 ,但感染合并症仍需严加防范 。

Objective To observe the curative effect of Immunedepressant MMF for lupus nephritis treatment and study the effective nursing method during the treatment.Methodology 23 cases of lupus nephritis at stage IV confirmed by biopsy were selected as sample, they has been treated by traditional immunedepressant or other means, but has no effect. All the patients were treated by MMF 0.25 to 2.0 g/day, among which, 21 combined by small dosage of hormone.Results After 12 months of treatment by MMF,5 cases renal function recovered from 8 renal insufficiency.3 cases get rid of dialysis. Urine protein decreased and reached to 50% of the base date in all cases. Blood in urine disappear among 28.5% cases. Side effect and digestive system symptom occupied 30.4%,2 cases has bacterial pneumonia, account for.8.7%,2 cases has shingles, account for 8.7%. no white blood cell decrease or liver insufficiency was observed.Conclusion MMF is effective and less sideeffect in trkstment lupus nephritis, but infectious complication needed to prevent,basic nursing needed to reinforce.