左氧氟沙星治疗感染性疾病60例

Levofloxacin in treating infective disease in 60 patients

目的 :探讨左氧氟沙星治疗感染性疾病的疗效并与环丙沙星比较。方法 :90例感染性病人分为观察组 60例 (男性 38例 ,女性 2 2例 ;年龄 67a±s10a) ,均用左氧氟沙星 ,其中 30例 (A组 ) 2 0 0mg ,qd ;另 30例 (B组 ) 10 0mg ,bid。对照组 30例 (男性13例 ,女性 17例 ;年龄 57a± 6a)用环丙沙星 2 0 0mg ,bid。 3组均iv ,drip× 7～ 14d。结果 :观察组总痊愈率 85% ,优于对照组 ( 53 % ) ,P <0 .0 5;A ,B 2组痊愈率 ( 83 %和 87% )及有效率 ( 97%和 90 % )差异均无显著意义 (P >0 .0 5)。结论 :左氧氟沙星治疗感染性疾病疗效优于环丙沙星 ;同等剂量一次与分次给药 。

AIM: To study the efficiency of levofloxacin and compare with ciprofloxacin in treating infective disease. METHODS: Ninety patients with infective disease were divided into two groups. The levofloxacin group of 60 patients (M 38, F 22; age 67 a±s 10 a) were treated with levofloxacin lactate injection. Among them the thirty patients were given 200 mg qd, and another thirty patients were given 100 mg bid. The control group of 30 patients (M 13,F 17; age 57 a±6 a) were given ciprofloxacin lactate injection 200 mg bid. Three groups all given by iv, drip×714d. RESULTS: The cure rates were 85 % in levofloxacin group and 53 % in the control group (P<0.05). The cure rates and effective rates were 83 % and 97 % in the first thirty patients and 87 % and 90 % in the second thirty patients (P> 0.05). CONCLUSION: Lavofloxacin have better effective than ciprofloxacin in the treatment of infective disease, and the similar efficiency can be observed with the same dose·d -1 qd or bid.