GRP78的表达与非小细胞肺癌生物学特性及预后的关系

The Relationship between Expression of GRP78 and Its Biological Characteristic,Prognosis in Non-Small Cell Lung Cancer

目的:探讨GRP78在非小细胞肺癌和癌旁组织中的表达情况,并研究其与生物学特征及临床预后的关系。方法:收集非小细胞肺癌术后切除标本88例,及其癌旁组织20例作为对照。采用免疫组织化学方法检测GRP78的表达。结果:GRP78在非小细胞肺癌组织和癌旁组织中的表达有统计学差异。GRP78的表达与非小细胞肺癌的临床分期、分化程度有关,而与患者性别、年龄和病理类型无关。非小细胞肺癌中GRP78高表达的患者生存时间短于GRP78低表达的患者。GRP78的表达情况是影响非小细胞肺癌患者手术预后的独立危险因素。结论:非小细胞肺癌患者的GRP78的表达可能与肿瘤细胞的发生及发展有关,GRP78可以作为一个预测非小细胞肺癌患者预后的分子标志物。

Objective：To explore the expression of endoplasmic reticulum stress molecular chaperone GRP78（glucose regulated protein,GRP78）in non-small cell lung cancer tissues and para-cancerous lung tissues.We investigated relationship between the expression of GRP78 and its biological characteristic,prognosis in non-small cell lung cancer.Methods：We collected 88 cases of surgically resected specimens in non-small cell lung cancer and 20 cases para-cancerous tissues for contrast.Immunohistochemistry method was used to detect the expression of GRP78 protein.Results：The expression of GRP78 in non-small cell lung cancer tissues and para-cancerous lung tissues had statistical significance.The levels of GRP78 expression were correlated with extent of differentiation,clinical stage,but not with patients＇ sex,age and pathologic features.GRP78 expression was independent prognotic factor of non-small cell lung cancer.Conclusions：The expression of GRP78 in non-small cell lung cancer tissues was related with non-small cell lung cancer development.GRP78 may be used as a molecular marker to prognosis of non-small cell lung cancer.