血浆B型脑钠肽对急性冠脉综合征的病情影响及预后评估

Plasma B-Type Natriuretic Peptide Role for Evaluation of Pathogenetic Condition and Outcome of Acute Coronary Syndrome

目的:探讨血浆B型脑钠肽(BNP)对急性冠脉综合征的病情影响及预后评估的作用,为临床实践提供参考。方法:分别对30例健康体检者(对照组)和81例ACS患者(观察组)检测其入院24小时内的血浆BNP浓度,并在住院一周内行冠状动脉造影术,检查病变的冠脉支数。结果:观察组的血浆BNP浓度高于对照(P<0.01),病变动脉支数与BNP水平呈正相关(P<0.01)。结论:BNP是急性冠脉综合征发病的重要因素,其水平高低可反映病情的严重程度,是预测病情和预后的重要指标。临床上应有效的监测BNP水平,对正确诊断和有效治疗急性冠脉综合征具有重要的意义。

Objective： To study the role of plasma B-type natriuretic peptide to evaluate the pathogenetic condition and outcome of acute coronary syndrome. Methods： 81 patients with ACS （observation group） and 30 health examination persons （controlling group） were enrolled in this study. Plasma levels of BNP were detected in 24 hours after hospitalization and coronary angiography were performed for detecting the affected coronary arteries in a week. Results： Plasma levels of BNP of the observation group were higher than those of the controlling group （P〈0.01）. The correlation was positive between the number of affected coronary arteries and the levels of BNP（P〈 0.01 ）. Conclusion： BNP was an important factor in the pathogenesy of ACS; the levels of BNP may reflect the severity of ACS, and BNP can be an important index to evaluate the pathogenetic condition and outcome. Monitoring the BNP level effectively in clinic possesses is considered significant significance to diagnose exactly and reasonable treatment for acute coronary syndrome.