射频热疗技术在脑胶质瘤治疗中的应用进展

Application of Brain Glioma Treatment with RF Hyperthermia

近几年,射频(radio frequency,RF)热疗技术以其靶向、微创、效果好,副作用少等特点,在临床治疗中,尤其是恶性肿瘤的治疗方面,取得了巨大的发展。随着研究的逐步深入,射频热疗技术越来越受到人们的重视,其应用范围也逐渐宽泛。脑胶质瘤呈广泛侵袭性生长,尤其是Ⅲ～Ⅳ级胶质瘤,具有高度间变的生长特点,术后复发快,手术加放化疗的平均生存期仅为8～11个月,严重威胁人类健康,是神经外科治疗领域中最难治疗的肿瘤。因而有关恶性脑胶质细胞瘤发生、发展及治疗的研究一直是神经外科领域的热点之一。本文就射频热疗技术的基本原理、脑胶质瘤治疗现状、射频热疗技术在脑胶质瘤治疗方面的应用,最新研究方向及进展做一综述。

Objective：In recent years,radio frequency（RF） hyperthermia technology with its targeted,minimally invasive,effective,almost having no side-effect and other characteristics,in the clinical treatment,especially in the treatment of malignant tumors,achieved great development.With the development of radio frequency technology,people pay more and more attention to it,and its scope of application is more and more wide.Glioma grows widely and invasively,especially III ～ IV glioma,with a highly variable growth characteristics,recurrence fast operation plus radiotherapy and chemotherapy.The mean survival time was only 8 to11 months,was a serious threat to human health,was in the field of neurosurgery in the treatment of refractory tumors.Some malignant glioma occurrence,development and treatment research is always the hot topic in the field of neurosurgery.Here,we review its basic principle of the technology of radio frequency hyperthermia,brain glioma treatment,radio frequency hyperthermia technique in the human glioma therapy application and advances.