柴胡加龙骨牡蛎汤加减配合心理治疗改善肿瘤患者抑郁症状的疗效观察

The therapeutic effect observation of Chaihu plus Longgumuli decoction combined with psychological therapy in cancer patients with depressive symptom

目的:观察柴胡加龙骨牡蛎汤加减配合心理治疗改善肿瘤患者抑郁症状的临床疗效。方法:选择符合入组条件的肿瘤患者120例,采用柴胡加龙骨牡蛎汤加减配合心理治疗组60例,并与对照组口服盐酸氟西汀胶囊组配合心理治疗组60例作对照。治疗组用柴胡加龙骨牡蛎汤,早晚温服,每次100mL,对照组口服盐酸氟西汀胶囊(百优解)20mg,每日1次,2组均以1周为1个疗程,连续6个疗程。在治疗前及治疗后第1、2、4、6周分别调查患者HAMD量表各项评判积分,并以治疗前后减分变化来评定疗效,并观察2组药物副作用。结果:该组方配合心理治疗不仅能够改善患者的抑郁状态,而且增强患者的免疫功能,相对于盐酸氟西汀胶囊虽然起作用较慢,但作用持久且无相关毒副作用。结论:柴胡加龙骨牡蛎汤加减配合心理治疗能够明显改善肿瘤患者抑郁症状,且能提高患者免疫功能,改善生活质量。

Objective： To observe the therapeutic effect of Chaihu plus Longgumuli decoction combined with psychological therapy in cancer patients with depressive symptom. Methods：A total of 120 eligible cases were randomly divided into two groups ,in which 60 cases of Chaihu plus Longgumuli decoction combined with psychological treatment group and 60 cases control group with oral fluoxetine hydrochloride capsules combined with psychological therapy group were included. The patients in Chaihu plus Longgumuli Decoction group were treated with Chaihu plus Longgumuli Decoction, administered warm morning and evening, each time 100ml ,and the patients in the control group were treated with fluoxetine hydrochloride capsules （ Prozac ）20 mg, once daily, a week for a cycle of treatment in each group , treated with 6 consecutive cycles. To investigate the evaluation points with HAMD scale before treatment and after 1,2,4, 6 weeks respectively in each group and to evaluate the effects with the change of minus points and immune function before and after treatment, the side effects of drugs were also observed in two groups. Results：The chinese medicine prescription with psychological therapy can not only improve their depression, but also enhance the immune function of patients with respect to fluoxetine hydrochloride capsules, although the effect of The chinese medicine prescription with psychological therapy is slower, but the lasting effect and no toxic side effect, were observed. Conclusion： Chaihu plus Longgumuli decoction combined with psychological treatment can significantly improve depressive symptoms and immune function to better the quality of life.