铜稳态对铁代谢平衡的影响

The role of copper in iron metabolism and homeostasis

铜是人体必需的微量元素,参与体内多种蛋白和酶的组成,机体内存在严格的铜稳态调控机制。作为血浆中最主要的多铜亚铁氧化酶——铜蓝蛋白,与另外两种同源亚铁氧化酶——膜铁转运辅助蛋白和zyklopen,共同参与体内铁的转运,维持铁代谢的平衡。将对调节铜和铁平衡的重要意义以及铜和铁在机体代谢过程中的相互作用、发展动态进行讨论。

Copper and iron are essential micronutrients involved in a variety of biological processes indispensable to life. These metals are closely connected in part by the requirement of multicopper ferroxidases for maintenance of normal iron homeostasis. Multicopper ferroxidases are critical for the efficient export of iron from cells throughout the body. Currently, three major multicopper ferroxidases have been identified： ceruloplasmin （Cp）, hephaestin （Hp）, and zyklopen （Zp）. This review highlights recent advances in copper-iron interactions with a focus on the tissues and cell types important for regulating whole-body copper and iron metabolism, and discusses extensive future research opportunities.