新清宁片的薄膜包衣工艺优选

Optimization of Film Coating Technology for Xinqingning Tablet

目的:优选新清宁片的薄膜包衣工艺。方法:采用正交试验,选取包衣液质量浓度、包衣液喷量、进风温度、包衣锅转数为考察因素,综合评分法优化新清宁片薄膜包衣的工艺参数。结果:薄膜包衣最佳工艺参数为包衣液质量浓度0.14 g.mL-1,包衣液喷量5.05～5.15 g.min-1,进风温度80℃,包衣锅转速6～8 r.min-1。结论:优选的薄膜包衣工艺稳定可行,可推广大生产应用。

Objective： To optimize film coating process of Xinqingning tablet. Method： Orthogonal test was used with the concentration of coating solution, the spray amount of coating solution, inlet air temperature and rotation of coating pan as factors, technology parameters of coating process were optimized by composite score method. Result： Optimum coating process parameters were： the concentration of coating solution 0. 14 g·mL-1, the spray amount of coating solution 5.05-5.15 g·min-1, inlet air temperature 80 ℃ , rotation of coating pan 6-8 r·min-1 Conclusion： This optimized technology was stable and feasible, it could be promoted to large-scale production.