麝香保心丸对慢性心力衰竭心功能及血浆NT-proBNP的影响

Influence of Shexiang Baoxin Pills on Cardiac Function and Content of NT-proBNP in Patients with Chronic Heart Failure

目的:观察麝香保心丸对慢性心力衰竭(CHF)心功能及血浆N-末端脑钠肽前体(NT-proBNP)的影响。方法:84例CHF患者随机分为治疗组和对照组各42例。对照组采用西医常规治疗,治疗组在西医常规治疗的基础上加用麝香保心丸。治疗4周后比较两组患者心功能及血浆NT-proBNP水平。结果:治疗后两组左室舒张末内径(LVEDD、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、心输出量(CO)及6 min步行距离均较治疗前有改善,治疗组改善的程度优于对照组(P<0.05,P<0.01);疗后治疗组血浆NT-proBNP水平低于对照组(P<0.05),疗后治疗组临床疗效优于对照组(P<0.05)。结论:麝香保心丸能显著改善CHF患者心脏舒缩功能,降低其血浆NT-proBNP水平。

Objective： To observe the influence of Shexiang Baoxin Pills （SBP） on the plasma nterminal-pro-brain natriuretic peptide （NT-proBNP） and the cardiac function in patients with chronic heart failure. Method： Eighty-four patients of chronic heart failure caused by coronary heart disease were randomly divided into treatment and control group （n = 42 each）. The control group was applied with routine treatment and the treatment group was given the routine treatment and SBP. After four weeks, the level of plasma NT-proBNP and the cardiac function were detected. Result： Compared with those before treatment, left ventricular end distolic diameter （LVEDD）, left ventricular ejection fraction （LVEF）, cardiac output （CO） and left ventricular and systolic diameter （LVESED） were improved obviously in both groups. However, these indices in the treatment group were better than those in the control group （P 〈 0.05, P 〈 0.01 ）. As plasma NT-proBNP was concerned, the reduce in the treatment group was more significantly than that of the control group （P 〈 0.05）. The clinical efficacy of the treatment group was more significantly than that of the control group （P 〈 0.05）. Conclusion： SBP can significantly enhance the cardiac systolic and diastolic function and decrease plasma level of NT-proBNP.