摘要
目的:探讨经皮冠状动脉介入治疗(PCI)术后白细胞介素(IL)-8/IL-10比值的变化及相关影响因素。方法:行冠状动脉造影(CAG)患者103例,其中稳定型心绞痛单纯造影组(SA1组)31例、稳定型心绞痛PCI组(SA2组)34例、不稳定型心绞痛PCI组(UA组)38例。检测各组患者PCI术前及术后24h血清高敏C-反应蛋白(hs-CRP)、IL-8及IL-10水平。结果:(1)SA2组及UA组术后IL-8/IL-10比值高于术前(P<0.05或P<0.01)。(2)术后UA组IL-8/IL-10比值均高于SA1及SA2组(P<0.05)。(3)术前IL-8/IL-10比值及不稳定型心绞痛状态是术后IL-8/IL-10比值的影响因素。结论:PCI术后存在促炎/抗炎细胞因子失衡,机体炎症反应增强,且以术前存在细胞因子失衡状态及不稳定型心绞痛患者更明显。
Objective： To investigate the changes of ratio of interleukin （IL）-8/IL-IO Serum Levels and the related factors after percutaneous coronary intervention （PCI）. Methods： A total of 103 patients undergoing coronary angiography （GAG） were divided into SA1 group （patients with stable angina only undergoing CAG, n=31）, SA2 group （patients with stable angina undergoing PCI, n=34） and UA group （patients with unstable angina undergoing PCI, n=38）. Blood samples were taken to evaluate serum concentrations of high-sensitivity C-reactive protein （hs-CRP）, IL-8 and IL-IO in patients just before PCI and 24 h after the procedure. Results： （1） In both SA2 group and UA group, the ratio of IL-8/IL-10 was higher after PCI than that before PCI （P 〈 0.05 or P 〈 0.01）. （2） After PCI, the ratio of IL-8/IL-10 was higher in UA group than that in both SA1 group and SA2 group （P 〈 0.05）. （3） The ratios of IL-8/IL-10 before PCI and the situation of unstable angina were correlated with the ratio of IL-8/IL-IO after PCI. Conclusion： There exists inflammatory cytokine imbalance after PCI, which triggers a systemic inflammatory response. Moreover, this response is more obvious in patients with inflammatory cytokine imbalance before PCI or with unstable angina.
出处
《天津医药》
CAS
北大核心
2012年第9期882-884,共3页
Tianjin Medical Journal
基金
广西卫生厅资助课题(项目编号:Z2010341)
