期刊文献+

Telaprevir联合治疗慢性丙型肝炎新进展 被引量:2

下载PDF
导出
摘要 在我国除了慢性乙型肝炎之外,慢性丙型肝炎(CHC)也是导致肝硬化、肝衰竭和肝癌的主要原因之一。目前全球约有1.8亿人感染丙型肝炎病毒(HCV),当前主要治疗方案是聚乙二醇干扰素(PEG—IFNα)联合利巴韦林(RBV)治疗,希望治疗后获得持久的病毒学应答(SVR),阻止疾病进展。近年来,通过PEG—IFNα联合RBV治疗(以下称标准治疗)已经取得了明显的疗效,尤其对HCV基因2型疗效更好。
出处 《肝脏》 2012年第7期521-523,共3页 Chinese Hepatology
  • 相关文献

参考文献30

  • 1McHutchison JG, 1.awitz EJ, Shiffman ML, et al. Peginterferon alfa 2b or alfa 2a with ribavirin for treatment of hepatitis C infection. N EnglJ Med, 2009,361:580- 593.
  • 2Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med, 2002,347 : 975-982.
  • 3Hadziyannis SJ, Sette H Jr, Morgan TR, et aL Peginterferon- alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med, 2004,140 : 346-355.
  • 4Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa 2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet, 2001, 358 : 958-965.
  • 5Simmonds P, Bukh J, Comber C, et al. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology, 2005,42 : 962-973.
  • 6Lindenbach BD, Rice CM. Unravelling hepatitis C virus replication from genome to function. Nature, 2005,436 : 933 -938.
  • 7Anzola M, Burgos JJ. Hepatoeellular carcinoma: molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis. Expert Rev Mol Med, 2003,5:1-16.
  • 8Foy E, Li K, Wang C, et al. Regulation of interferon regulatory :actor 3 by the hepatitis C virus serine protease. Science, 2003, 300:1145-1148.
  • 9Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med, 2011, 364t2417-2428.
  • 10Jacobson IM, MeHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med, 2011,364:2405-2416.

同被引文献20

  • 1Katz LH, Goldvaser H, Gafter-Gvili A, et al. Extended peginterferon plus ribavirin treatment for 72 weeks versus standard peginterferon plus ribavirin treatment for 48 weeks in chronic hepatitis C genotype 1 infected slow-responder adult patients [J]. Coehrane Database Syst Rev, 2012, 9 : CD008516.
  • 2Liu CH, Huang CF, Liu CJ, et al. Pegylated interferon-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 1 receiving hemodialysis = a randomized trial [J]. Ann Intern Med, 2013, 159(11) ..729-738.
  • 3Rollet-Kurhajec KC, Moodie EE, Walmsley S, et al. Hepatic Fibrosis Progression in HIV-Hepatitis C Virus Co-Infection - The Effect of Sex on Risk of Significant Fibrosis Measured by Aspartate-to-Platelet Ratio Index [J]. PLoS One, 2015, 10 (6) :129868.
  • 4Blonski W, Reddy KR. Hepatitis C virus infection and hepatocellular carcinoma [ J ]. Clin Liver Dis, 2008, 12 ( 3 ) : 661-674.
  • 5Saito T, Owen DM,Jiang F, et a l. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA[J]. Nature,2008,454(7203) :523-527.
  • 6Mohd Hanafiah K, Groeger J, Flaxman AD, et al. Global epidemiology of hepatitis C virus infection New estimates of age - specific antibody to HCV seroprevalence [ J ].Hepatology, 2013,57(4) : 1333-1342.
  • 7陈冬玲,冯淑焕,李萍,田瑞民,姜达琳.聚乙二醇干扰素α-2α与利巴韦林联合胸腺肽α1治疗慢性丙型肝炎疗效观察[J].现代医药卫生,2010,26(6):901-901. 被引量:1
  • 8谭英征,陈双华,傅京力,龙云铸,李丹,邓意.聚乙二醇干扰素α-2a和重组人干扰素α-2b治疗慢性丙肝临床疗效观察[J].实用临床医药杂志,2010,14(8):75-76. 被引量:17
  • 9饶慧瑛,魏来.欧洲肝病学会2011年丙型肝炎诊治指南介绍[J].中华肝脏病杂志,2011,19(5):391-394. 被引量:35
  • 10杨臻峥.抗丙型肝炎病毒药Boceprevir[J].药学进展,2011,35(7):332-333. 被引量:3

引证文献2

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部