长脉冲1064nm Nd:YAG激光治疗婴幼儿皮肤血管瘤215例疗效分析

A clinical effect analysis of long-pulsed 1064 nm Nd:YAG laser in the treatment of 215 infancy hemangiomas

目的:观察长脉冲1 064 nm Nd:YAG激光治疗婴幼儿皮肤血管瘤临床疗效,并探讨影响疗效的相关因素。方法:应用长脉冲1 064 nm Nd:YAG激光治疗婴幼儿皮肤血管瘤215例,其中鲜红斑痣19例,草莓状血管瘤179例,混合型血管瘤17例。分析其疗效与病变类型、瘤体大小、病变部位及治疗次数的关系。结果:215例患儿中治愈133例,显效67例,有效8例,无效7例,痊愈率和有效率分别为61.9%和93.1%。疗效与血管瘤的病变类型、瘤体的大小以及治疗次数有关,但与其病变部位无明显相关性。治疗后暂时性色素沉着、暂时性色素减退、浅表性瘢痕、头部毛发减少或消失的发生率分别为48.8%、8.3%、4.6%和3.7%。结论:长脉冲1 064 nm Nd:YAG激光治疗婴幼儿皮肤血管瘤疗效好,安全性较高,不良反应轻,可在临床上推广使用。

Objectives： To observe the clinical effects of long-pulsed 1 064 nm Nd：YAG laser in the treatment of hemangiomas of skin in infant and investigate its related factors. Methods： Total 215 cases were treated with long-pulsed 1 064 nm Nd：YAG laser according to different disease types, including 19 cases of port wine stains, 179 cases of strawbeny hemangiomas and 17 cases of mixed hemangiomas. The association between clinical effect and types, size, location and times of treatment of hemangiomas was also analyzed. Results： Among 215 cases, 133 were cured, 67 gained marked effect, 8 gaining effective therapy and 7 ineffective. The cure rate and total efficacy rate were 61.9% and 93.1%, respectively. The effect was related with the type, size and treatment times of hemangiomas. However, the location of hemangiomas was not associated with the therapy effect. The side-effect rate was 48.8% with temporary hyper-pigmentation, 8.3% with temporary hypo-pigmentation, 4.6% with superficial scar and 3.7% with hair reduction or disappearance. Conclusion： The long-pulsed 1 064rim Nd：YAG laser is an effective, safe and low side-effect treatment for infancy hemangiomas.