益生菌在治疗难治性幽门螺杆菌感染中的价值

The Value of Pobiotics in the Treatment of Refractory Helicobacter Pylori Infection

目的探讨益生菌在治疗难治性幽门螺杆菌(Hp)感染中的价值。方法 90例Hp感染慢性胃炎患者经三联根治疗法治疗失败后随机分成益生菌治疗组和对照组。治疗组48例给予益生菌+四联疗法,对照组42例单给四联疗法,比较两组的临床疗效、Hp根除率明及副作用发生情况。结果益生菌治疗组的症状改善率及Hp根除率明显高于对照组(95.8%vs 83.3%、93.8%vs 81.0%),有统计学差异(P<0.05)。同时治疗组副作用发生率明显低于对照组(14.6%vs 23.8%),有统计学差异(P<0.05)。结论益生菌能有效提高难治性Hp的根除率,改善临床症状且减少药物的副作用。

Objective To explore the value of probiotics in the treatment of refractory helicobacter pylori （Hp） infec- tion. Methods 90 cases of patients with chronic gastritis treated with failure trigeminy Hp- eradicational treatment were ran- domly divided into two groups, the probiotics treatment group and control group. 48 cases of patients in the treatment group were treated with probiotics and quadruple Hp-eradicational therapy. And another 48 cases were treated with only quadruple Hp- eradicational therapy. The difference was compared between the two groups including the clinical efficacy, the rate of Hp- eradi- cation and side effects. Results （ 1 ） The rate of clinical symptom alleviation and Hp- eradication in the probiotie- treatment group was much higher than the controls（95.8% vs 83.3% ,93.8% vs 81.0% ） ,which had statistical difference （P 〈0.05）. Meanwhile,the rate of side effects in the p,＇obiotic- treatment group was much lower than the controls（ 14.6% vs 23.8% ）, which had statistical difference （ P 〈 0.05 ）. Conclusion The probiotics can effectively improve the rate of refractory Hp-erad- ication. They can also improve the clinical symptom and decrease the incidence of side effects.