十二烷基苯磺酸钠对雄性小鼠生育力的影响

Effect of sodium dodecyl benzene sulfonate on reproduction of male mice

目的:探讨十二烷基苯磺酸钠(SDBS)对雄性小鼠生育力的影响。方法:分别将120只昆明种雌、雄性小鼠随机分为4组,每组30只。A组为与染毒SDBS两个月后的雄性小鼠交配的雌鼠;B组为与染毒SDBS两个月,停止染毒一个月后的雄鼠交配的雌鼠。A、B两组分别设对照组为a组、b组。对各组怀孕率、孕鼠平均产子数及其胎鼠情况进行比较分析。结果:与对照组相比,A、B两组的怀孕率、孕鼠平均产子数、孕鼠腹中死胎、畸胎与吸收胎比例明显降低,有显著性差异(P<0.05);A、B两组相比,小鼠怀孕率、孕鼠平均产子数、孕鼠腹中死胎、畸胎与吸收胎比例无显著性差异(P>0.05)。结论:十二烷基苯磺酸钠对雄性小鼠的生育力有显著影响,并且在停止染毒后的短时期内不能恢复。

Objective： To determine the effects of sodium dodecyl benzene sulfonate （SDBS） on reproduction of male mice. Methods： Both 120 Kunming male mice and 120 female mice were randomly divided into four groups and the number of every group was 30. Group A was the female mice which were mated with the male mice gavaged by SDBS for two months; Group B was the female mice which were mated with the male mice garaged by SDBS for two months and stopped for one month. Group a and group b were the control groups respectively. The pregnancy rates, the average birth number of pregnant rats and the fetal rats of these groups were studied. Results： The preg- nancy rates, the average birth number of pregnant rats and the proportion of deaths, malformation and absorbed fetuses in pregnant rats was lower than the control groups, there was significant difference（P 〈 0.05 ）. However, there was no significant difference between group A and group B（ P 〉 0.05）. Conclusion： Sodium dodecyl benzene sul- fonate have.an significant toxicity effect on the reproduction of male mice and they cannot restore after leaving off being gavaged for a short time.