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胱抑素C在2型糖尿病肾病患者早期的检测及意义 被引量:5

Significance of cystatin C in type 2 diabetic nephropathy patients
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摘要 目的:血清和尿液探索胱抑素C在预测2型糖尿病肾病患者蛋白正常时肾功能损害的临床意义,评价其与蛋白尿的关系。方法:将232例患者分成3组:正常蛋白尿组、微量白蛋白尿组和大量白蛋白尿组,检测肌酐、尿白蛋白、血清/尿胱抑素C、肾小球滤过率(eGFR、MDRD计算的eGFR和CKD-EPI计算的eGFR)。结果:胱抑素C随尿蛋白的增加而增加。血清胱抑素C受CRP、性别、尿白蛋白/肌酐比值和eGFR影响,而尿胱抑素C受甘油三酯、年龄、eGFR和ACR影响。胱抑素C在正常蛋白尿组MDRD计算的eGFR<60 ml/min/1.73 m2中是独立因子。结论:胱抑素C在诊断2型糖尿病肾病尿蛋白正常时为有用的指标。 Objective:To evaluate clinical usefulness of cystatin C levels in serum and urine in predicting renal impairment in normoalbuminuric patients with type 2 diabetes and to evaluate the association between albuminuria and serum/urine cystatin C. Methods: 232 type 2 diabetic patients with normoalbuminuria, microalbuminuria and macroalbuminuria were enrolled. Creatinine, urinary albumin levels, serum/urine cystatin C and estimated glomeru- lar filtration rate ( eGFR by MDRD and CKD - EPIequations) were determined. Results : The cystatin C levels of serum and urine increased with increasing degree of albuminuria. Serum cystatin C was affected by C - reactive protein (CRP), sex, albumin -creatinine ratio (ACR) and eGFR. Urine eystatin C was affected by triglyeeride, age, eGFR and ACR. Cystatin C levels of serum and urine were identified as independent factors associated with eGFR 〈 60 ml/min/1.73 m^2 estimated by MDRD equation in patients with normoalbuminuria. Conclusion: The cystatin C levels could be useful markers for renal dysfunction in type 2 diabetic patients with normoalbuminuria.
出处 《中国卫生检验杂志》 北大核心 2012年第8期1875-1877,共3页 Chinese Journal of Health Laboratory Technology
关键词 胱抑素C 糖尿病肾病 蛋白尿 Cystatin C Diabetic Nephropathies Albuminuria
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  • 1Stevens LA, schimid CH, Greene T. FactoB otller than glomemlar filtration rate affect serum eystafin C leveis[ J]. Kidney Int,2009, 75:652 - 660.
  • 2陈灏珠.实用内科学[M].第12版.北京:人民卫生出版社,2006.1895-1896.
  • 3姚迪,黄晶,伦志军,于金海.Cystatinc在早期诊断糖尿病肾损害中的意义[J].中国实验诊断学,2009,13(10):1389-1390. 被引量:16

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  • 1俸家富,罗军,李少林.胱抑素C——肾小球滤过率肌酐替代标记物[J].国外医学(临床生物化学与检验学分册),2005,26(3):168-172. 被引量:112
  • 2程苏琴,朱美财.尿微量白蛋白在糖尿病肾损伤早期诊断中的价值[J].中华检验医学杂志,2005,28(7):740-741. 被引量:203
  • 3Choe JY, Park SH, Kim SK. Serum cystatin C is a potential endogenous marker for the estimation of renal function in male gout patients with renal impairment[J]. J Korean Med Sci,2010,25(1) :42-48.
  • 4Rigalleau V, Beauvieux MC, Le Moigne F, et al. Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes[J]. Diabetes Metab, 2008,34 (5) : 482-489.
  • 5Pucci L, Triscornia S, Lucchesi D, et al. Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients [J]. Clin Chem, 2007, 53 (3) :480-488.
  • 6Borges RI, Himta AH, Quinto BM, et al. Is cystatin C a useful marker intbe detection of diabetic kidney discase [ J ]. Nephron Clin Praet, 2009,114(2) :127.
  • 7Perkins BA, Nelson RG, Ostrander BE, et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration : re- suits of a 4-year follow-up study [ J ]. J Am Soc Nephrol, 2005, 16(5) :1404-1412.
  • 8Swiatio E, King J, Nabors CS, et al. Pneumocoeeal surfaceprotein A is expressed in vivo, and antibodies to Psp A are effectivefor therapy in a murine model of pnemococcal sepsis [J ]. InfectIm- mum, 2003,71 (12) :7149.
  • 9Hating N, Mahr HS, Mundle M, et al. Early detection of renal- damage caused by fumaric acid estertherapy by determination ofuri- nary 132-microglobulin [ J ]. Dr J Dermatol, 2011,164 ( 3 ) : 648.
  • 10Dehghan A, Van Hoek M, Sijbrands E J G, et al.High serum uric acid as a novel risk factor for type 2 diabetes[J].Diabetes Care, 2008, 31(2):361-362.

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