摘要
目的:对穆库没药甾体类化学成分进行系统研究。方法:采用硅胶柱色谱、ODS柱色谱及制备HPLC等方法分离纯化,运用现代光谱学方法鉴定化合物结构。结果:从穆库没药中分离得到5个化合物,分别鉴定为4,17(20)-(cis)-pregnad-iene-3,16-dione(1)、progesterone(2)、20-acetyloxy4-pregnene-3,16-dione(3)、Z-4,17(20)-pregnadiene-3,16-dione(Z-Gugguls-terone)(4)、E4,17(20)-pregnadiene-3,16-dione(E-Guggulsterone)(5)。结论:化合物1-2从穆库没药中首次分离得到。
Objective: To study the steroids constituents in Commiphora mukul. Method: The compounds were separated by various column chromatography methods including silica gel column (CC), ODS (CC) and preparative HPLC. The structures were elucidated by modern spectral analysis. Result: Five compounds were obtained and identified as follows: 4,17 (20)- (cis)-pregnadiene-3, 16-dione ( 1 ), progesterone ( 2 ) , 20-acetyloxy-4-pregnene-3,16-dione ( 3 ), Z-4,17 ( 20 ) -pregnadiene-3,16-dione ( Z-Guggulsterone ) (4) and E-4,17 (20) -pregnadiene-3,16-dione (E-Guggulsterone) ( 5 ). Conclusion: Compound 1 and 2 are isolated from Commiphora mukul for the first time.
出处
《中国药师》
CAS
2012年第7期917-919,共3页
China Pharmacist
基金
国家科技支撑计划[编号:2012(BAI30802)]
石河子大学科学技术研究发展计划(编号:ZRKX2009ZD05)
关键词
穆库没药
甾体
结构鉴定
Commiphora mukul
Steroids
Structure identification