肝乐舒颗粒的质量标准研究

Study on Quality Standard of Ganleshu Granules

目的:建立肝乐舒颗粒的质量标准。方法:采用TLC法对方中的灵芝、五味子进行定性鉴别;采用HPLC法对处方中的丹参酮ⅡA进行含量测定。结果:TLC斑点清晰、分离度好、专属性强,阴性对照无干扰;丹参酮ⅡA的进样量在0.2～4.0μg范围内与峰面积积分值呈良好线性关系,平均回收率98.34%,RSD=1.86%(n=5)。结论:所建标准能有效控制肝乐舒颗粒的质量。

Objective ： To establish the quality standard of Ganlesh, n granules. Method： TLC was employed to identify Ganoderma lucidum and Schisandra chinensis. Tanshinone IIs in Ganleshu granules was determined by HPLC. Result： TLC spots were clear, well - separated and specific without interference of the negative control. The linear range of tanshinone ⅡA was 0.2 - 4.0 p,g with the average recovery of 98.34% （ RSD = 1.86% , n = 5 ）. Conclusion： The established standard is suitable for the quality control of Ganleshu ganules.