单唾液酸神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病的临床观察

Clinical observation of GM1 combined with hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy

目的探讨单唾液酸神经节苷脂(GM1)联合高压氧治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法回顾性分析我院2004年3月—2010年8月收治的122例HIE患儿的临床资料。结果观察组总有效率为95.35%,对照组为81.40%,两组比较,差异有统计学意义(P<0.05)。两组在症状体征改善及后遗症发生率比较,差异有统计学意义(P<0.05)。结论单唾液酸神经节苷脂联合高压氧治疗HIE患儿中枢神经系统功能恢复有明显的促进作用。

Objective To investigate the clinical efficacy of the GM1 combined with hyperbaric oxygen in the treatment of neonatal hypoxic ischemic encephalopathy（HIE）. Methods In our hospital from March 2004 to August 2010,the data of 122 children with HIE were retrospectively analyzed. Results The total effective rate in the observation group was 95.35%,the total effective rate in the control group was 81.40%,there was a statistical significant difference between the two groups（P0.05）.There were statistical significant differences of the improvement of symptoms and signs and the incidence of complications between the two groups（P0.05）. Conclusion The GM1 treatment of children with HIE could significantly promote the central nervous system functional recovery.