不明原因中枢神经系统疾病患者弓形虫感染的血清学调查

Serological investigation on Toxoplasma gondii infection in patients with unknown central nervous system diseases

选择207例不明原因中枢神经系统疾病患者作为病例组,203例健康体检者为对照组,对其血清弓形虫特异性IgG抗体进行检测。病例组弓形虫抗体阳性率为19.81%,对照组为5.42%,两者差异有统计学意义(P<0.01)。病例组中脑型、癫痫型、精神病型和神经衰弱型患者血清弓形虫抗体阳性率分别为22.81%、24.32%、16.05%和18.75%,均显著高于对照组(P<0.01)。患者中有猫犬等宠物接触史者和无猫犬等宠物接触史者抗体阳性率分别为32.97%和9.48%,两者差异有统计学意义(P<0.01)。不明原因中枢神经系统疾病患者的弓形虫感染率明显高于普通人群,临床上对其开展弓形虫感染检测具有十分重要的意义。

Totally 207 patients with unknown central nervous system diseases and 203 healthy persons were investigated for serum IgG of anti-Toxoplasma antibody assessed by ELISA.The serum IgG positive rate in 207 patients with unknown central nervous system diseases was 19.81%,and that in 203 health people was 5.42%,and there was a significant difference between them（P0.01）.The IgG positive rates in different types of central nervous system diseases were different,which were 22.81%,24.32%,16.05%,and 18.75%,respectively in encephalopathy,epilepsy,mental disorder and neurasthenia.The IgG positive rate in different types of central nervous system diseases were significantly higher than that in healthy population（P0.01）.The IgG positive rates in patients who contacted or did not contact cats or dogs were 32.97% and 9.48% respectively（P0.01）.In conclusion,the infection rate in patients with unknown central nervous system diseases is higher than that in healthy persons;therefore,it is necessary to assay the serum IgG in them.