氩绿激光联合中药治疗糖尿病黄斑水肿

Argon green laser combined with traditional Chinese medicine for the treatment of diabetic macular edema

目的:探讨使用氩绿激光联合中药治疗糖尿病黄斑水肿(diabetic macular edema,DME)的疗效。方法:选择2010-08/2011-06收治的糖尿病水肿患者68例132眼。随机分为治疗组35例68眼,对照组33例64眼。治疗组使用氩绿激光联合中药治疗糖尿病黄斑水肿,对照组单纯使用氩绿激光治疗糖尿病黄斑水肿。6mo后行视力、眼底荧光素造影、OCT检查,并行统计学检验。结果:治疗后6mo,行视力检查,治疗组视力提高或稳定62眼(91.2%),视力下降6眼(8.8%)。对照组视力提高或稳定49眼(76.6%),视力下降15眼(23.4%)。P<0.05,两组比较有统计学意义。荧光素造影检查显示治疗组黄斑水肿部分消退或完全消退63眼(92.7%),水肿未消退5眼(7.3%),对照组黄斑水肿部分消退或完全消退50眼(78.1%),水肿未消退14眼(21.9%),两组比较有统计学意义(P<0.05)。光学相干断层扫描,治疗组黄斑水肿减轻或稳定61眼(89.8%),水肿不变或加重7眼(10.2%),对照组黄斑水肿减轻或稳定44眼(68.8%),水肿不变或加重20眼(31.2%)。两组比较有统计学意义(P<0.05)。结论:使用氩绿激光联合中药治疗糖尿病黄斑水肿是安全有效的方法。

AIM：To investigate the use of argon green laser photocoagulation combined with traditional Chinese medicine treatment of diabetic macular edema （diabetic macular edema, DME） efficacy.METHODS：Totally 68 cases （132 eyes） with diabetic edema during August 2010 to June 2011 were colected. All the cases were randomly divided into two groups：treatment group of 35 cases （68 eyes）, control group of 33 cases （64 eyes）. Treatment group used argon green laser combined with traditional Chinese medicine for the treatment of DEM, control group was treated with argon green laser only. After 6 months, visual acuity, fundus fluorescein angiography（FFA）, optic coherence tomography（OCT） were exmanied and statistical analysis were performed.RESULTS：Six months after treatment, visual acuity of treatment group improved or stabilized in 62 eyes （91.2%）, decreased in 6 eyes （8.8%）. Visual acuity of control group improved or stabilized in 49 eyes （76.6%）, decreased in 15 eyes （23.4%）. There was statistical significance between two groups （P0.05）. FFA showed that macular edema partial or complete regressed in 63 eyes （92.7%）, did not disappear in 5 eyes （7.3%） in treatment group. Macular edema partial or complete regressed in 50 eyes （78.1%）,did not disappear in 14 eyes（21.9%）in control group. There was statistical significance between two groups （P0.05）. OCT showed that macular edema in treatment groupalleviated or stabilized in 61 eyes （89.8%）, unchanged or aggravated in 7 eyes （10.2%）. Macular edema in control group alleviated or stabilized in 44 eyes （68.8%）, unchanged or increased in 20 eyes （31.2%）. Comparison of the two groups was statistically significant （P0.05 ）.CONCLUSION：Argon green laser photocoagulation combined with traditional Chinese medicine for treatment of DEM is safe and effective.