Bcl-2和MMP-9在翼状胬肉中的表达及意义

Expression and meaning of Bcl-2 and MMP-9 in pterygium

目的:研究翼状胬肉组织中Bcl-2和基质金属蛋白酶-9(MMP-9)的表达,以探讨Bcl-2和MMP-9表达与翼状胬肉之间的关系,为翼状胬肉的治疗提供理论依据。方法:应用免疫组织化学法检测76例翼状胬肉组织中Bcl-2和MMP-9的表达,并与9例正常结膜组织进行比较。结果:翼状胬肉组织中Bcl-2和MMP-9的表达均高于正常结膜组织。翼状胬肉组织中Bcl-2和MMP-9阳性表达间存在正相关(P<0.05)。结论:Bcl-2和MMP-9的高表达在翼状胬肉的发生和发展中起着重要作用。

ATM：To study the expression and the relationship of B-cell lymphoma/leukemia-2 （Bcl-2 ）and matrix metalloproteinases-9（MMP-9） in pterygium, and to provide the theory basis for the treatment of pterygium.METHODS：The expression of Bcl-2 and MMP-9 were detected in 76 cases with pterygium by immunohistochemical method and were compared with the normal conjunctiva epithelium in other 9 cases.RESULTS：The expression of Bcl-2 and MMP-9 was higher in pterygium than in normal conjunctiva epithelium（P0.05）.The expression of Bcl-2 was related to that of MMP-9.CONCLUSION：The increase of Bcl-2 and MMP-9 are presented in pterygium, which may play an important role in the origin and development of pterygium .