毛果芸香碱用于治疗前房积血安全性的探讨

Safety discussion of pilocarpine for the treatment of hyphema

目的:探讨毛果芸香碱眼液用于治疗前房积血后的疗效及安全性。方法:对我院收治的Ⅰ级和Ⅱ级前房积血患者87例87眼进行随机分组,实验组治疗过程中使用毛果芸香碱眼液,对照组仅采用常规治疗,观察分析治疗过程中再出血发生率及积血吸收治疗时间的情况。结果:两组病例观察后发现再出血率无差异,而积血吸收治疗时间实验组明显缩短。结论:毛果芸香碱眼液是一种安全有效的药物,在前房积血停止出血2d后及时使用,可有效缩短积血吸收时间,且治疗过程中再出血发生率无显著增高,值得在临床推广运用。

AIM：To investigate the effects and safety of pilocarpine for the treatment of anterior chamber hyphema.METHODS：There were 87 cases（87 eyes） with grade I and II anterior chamber hyphema in our hospital, which were randomly divided into experimental group and control group. The control group was treated by conventional method. The experimental group used conventional treatment and pilocarpine in additon. Secondary hemorrhage rate and blood absorption time during treatment were observed and analyzed.RESULTS：The secondary hemorrhage rate was no difference in two groups, while the blood absorption time was obviously shorter in experimental group.CONCLUSION：Pilocarpine eye drops is a safe and effective drug. It can shorten the blood absorption time effectively when timely use 2 days after anterior chamber hyphema stop bleeding, the secondary hemorrhage rate was not increased during the treatment. It is worthy of popularizing in clinic.