酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究(英文)

Synthesis,Structures,and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

本文合成了2个新的结构类似的酰腙氧钒(Ⅴ)配合物,[VOL(OCH3)(CH3OH)](L=L1=2-氯-N′-(5-氯-2-羟基苯亚甲基)苯甲酰肼(1);L=L2=2-氯-N′-(2-羟基-3-甲氧基苯亚甲基)苯甲酰肼(2)),并通过物理化学方法和单晶X-射线衍射表征了它们的结构。在每个配合物中,V原子都采取八面体配位构型,利用配体L中的3个给体原子和1个甲氧配体的氧原子定义其赤道面,利用1个酮氧原子和1个甲醇氧原子占据其2个轴向位置。本文还研究了这2个配合物对幽门螺旋杆菌脲酶的抑制活性。在浓度为100μmol.L-1时,配合物1和2对脲酶的抑制率分别为(82.0%±2.8%)和(28.2%±1.7%)。此外,还做了配合物和幽门螺旋杆菌脲酶的分子对接研究。

Two new structural similar oxovanadium（Ⅴ） complexes with the formulae [VOL（OCH3）（CH3OH）]（L=L1= 2-chloro-N′-（5-chloro-2-hydroxybenzylidene）benzohydrazide（1）;L=L2=2-chloro-N′-（2-hydroxy-3-methoxybenzyli-dene）benzohydrazide（2））,have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction.The V atom in each complex is in an octahedral coordination,with the three donor atoms of L and one methanolato O atom defining the equatorial plane,and with one oxo O atom and one methanol O atom occupying the axial positions.The complexes were evaluated for their urease inhibitory activities.The percent inhibition of the complexes 1 and 2 at the concentration of 100 μmol.L-1 on Helicobacter pylori urease are 82.0%±2.8% and 28.2%±1.7%.The molecular docking study of the complexes with the urease was performed.