垂体瘤转化基因诱导血管内皮生长因子的分子机制

Molecular mechanisms underlying the induction of vascular endothelial growth factor expression by pituitary tumor transforming gene

血管内皮生长因子是一个强大的促血管新生的生长因子，而垂体瘤转化基因可以通过诱导VEGF的表达进而促进肿瘤血管新生。与垂体瘤转化基因结合因子及Spl蛋白结合后，垂体瘤转化基因不仅能反式激活DNA结合抑制因子-3和成纤维细胞生长因子-2，而且可通过其他途径调节基质水解蛋白酶-2、凝血酶反应蛋白-1以及硫氧还蛋白-1的转录，上述因子又参与了垂体瘤转化基因诱导血管内皮生长因子的表达。

Pituitary tumor transforming gene （PTrG） can induce the expression of vascular endothelial growth factor （VEGF）, one of the most important angiogenie growth factors for tumor angiogenesis, to promote tumor angiogenesis. It has been revealed that PTTG can transactivate the inhibitor of DNA binding-3 （ID3） and fibroblast growth factor-2 （FGF-2） by interacting with PTTG binding factor （PBF） and specificity protein 1 （Spl）. PTTG can also regulate the transcription of matrix metalloproteinase-2 （MMP-2）, thrombospondin-1 （TSP-1） and thioredoxin-1 （Trx-1） through other pathways, which are all involved in the mechanisms underlying the induction of VEGF expression by PTTG.