毛囊干细胞在脱发性疾病中的研究进展

Hair follicle stem cells in disorders characterized by alopecia

脱发性疾病在临床比较常见，一般按临床表现和毛发是否可再生而将脱发分为瘢痕性脱发和非瘢痕性脱发，每种均包含了多种不同的脱发性疾病。目前脱发性疾病的发病机制仍不甚清楚。毛囊干细胞位于毛囊隆突区，其周期性地增殖和分化维持了毛发的正常生长、脱落与更替。研究表明，毛囊干细胞的损伤或缺失很可能参与了某些脱发性疾病尤其是瘢痕性脱发的发病过程。

Alopecia, as a common disease, is generally classified into two groups, cicatricial and noncicatricial alopecia, according to clinical presentations and regrowth capability of hairs, and each group includes various types of alopecia. The pathogenesis of alopecia remains poorly understood. Hair follicle stem cells are located in the bulge area, whose periodic proliferation and differentiation sustain the growth, shedding and regrowth of hairs. Recent research has indicated that the damage or deficiency of hair follicle stem cells may contribute to the pathogenesis of some types of alopecia, especially eicatricial alopecia.