期刊文献+

以紫癜为首发症状的原发性干燥综合征6例临床分析 被引量:11

A Clinical Analysis of Six Cases Suffering from Primary Sjogren’s Syndrome with Purpura as Initial Presentation
下载PDF
导出
摘要 目的分析以紫癜为首发临床表现的原发性干燥综合征(pSS)患者的临床特征,提高临床医生对本病的认识。方法回顾性分析本科2006年1月-2011年6月收治的6例以紫癜为首发表现的原发性干燥综合征患者的临床资料,包括首诊、临床症状、实验室检查、系统表现、治疗结果及随访情况。结果 6例均被误诊,首诊病程均未见记录眼睛干涩及口干症状,实验室检查结果见结缔组织病样特征,予个体化免疫抑制治疗10d~4周后患者皮疹均消退,血IgG治疗前为(2366.67±754.63)mg/dL,治疗后下降至(1936.67±322.22)mg/dL,总体疾病活动指数也下降,仅1例在药物减量后皮疹复发。结论 pSS患者出现紫癜样皮疹易被误诊,全面了解本病特征,结合典型结缔组织实验室检查结果即可确诊本病。本病可能系高球蛋白所致,抗过敏治疗效果欠佳,个体化规律免疫抑制效果佳。 Objective By retrospective clinical analysis of primary Sjogren' s syndrome with purpura as the initial presentation in 6 cases, to provide a reference for clinical diagnosis and treatment. Methods The clinical data, related laboratory tests,treatment and follow-up data of the 6 cases were collected. Results i^k patients all had misdiagnosised, dryness of mouth and eyes, other system complications and different laboratory examina- tions could be helpful to making correct diagnosis. After treated with individualized immunosuppressive thera- py and observated for 10 days -4 weeks , the rash subsided, IgG decreased from(2 366.67 ±754.63)mg/dL to (1 936.67 ±322.22)mg/dL,index of disease activity also decreased. The disease has less recurrence. Conclusion The onset of purpura in pSS is easy to make misdiagnosis or missed diagnosis, more clinical material and laboratory examinations should be in consideration. The mechanism may be due to the high globulin. Anti-allergy treatment is ineffective, the law of immunosuppressive therapy is easy to control.
出处 《中国皮肤性病学杂志》 CAS 北大核心 2012年第9期810-812,共3页 The Chinese Journal of Dermatovenereology
关键词 紫癜 干燥综合征 原发性 Purpura Sjogren' s syndrome, primary
  • 相关文献

参考文献7

  • 1Vitali C, Bombardieri S,Jonsson R, et al. Classification criteria Sjogren' s syndrome: a revised version of the European criteria proposed by the A- merican-European Consensus Group [ J ]. Ann Rheum Dis, 2002,61 (6) :554 -558.
  • 2Raphaele S, Philippe R, Simon B, et al. EULAR Sjogren' s Syndrome Disease Activity Index (ESSDAI) : Development of a consensus system- ic disease activity index in primary Sjogren's syndrome [ J ]. Ann Rheum Dis doi,2010,69(6) :1103 -1109.
  • 3Friedman JA, Miller EB. Comment on: Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren' s syndrome[ J]. Rheumatology (Oxford) ,2007,46 (2) :370 - 371.
  • 4干燥综合征诊治指南(草案)[J].中华风湿病学杂志,2003,7(7):446-448. 被引量:186
  • 5厉小梅,李向培,汪国生,钱龙,王玮.白芍总苷治疗干燥综合征的有效性和安全性评价[J].安徽医学,2006,27(5):370-371. 被引量:17
  • 6张洪峰,侯平,肖卫国.白芍总苷治疗非系统受累干燥综合征的临床观察[J].中国中西医结合杂志,2007,27(7):596-598. 被引量:29
  • 7Capra JD, Winchester RJ, Kunkel HG. Hypergammaglobulinemic pur- pura. Studies on the unusual anti--globulins characteristic of the sera of these patients [ J ]. Medicine ( Baltimore), 1971,50 (2) : 125 - 138.

二级参考文献14

共引文献223

同被引文献71

引证文献11

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部