抗纤溶治疗对急性早幼粒细胞白血病合并DIC患者脏器功能影响的研究

Analysis of effect of antifibrinolytic therapy on organ function of acute promyelocytic leukemia patients with DIC

目的:探讨抗纤溶治疗对急性早幼粒细胞白血病(APL)合并弥漫性血管内凝血(DIC)患者脏器功能的影响。方法:将满足入选标准的21例APL合并DIC患者采用自身前后对照研究的方法进行研究,均给予全反式维A酸(ATRA)诱导分化治疗,同时给予0.9%NS 250ml+止血芳酸3.0g ivgtt抗纤溶治疗,观察抗纤溶治疗1周对患者肝功、肾功、呼吸频率的影响。结果:抗纤溶治疗前后,满足入选标准的APL合并DIC患者的ALT、总胆红素、血肌酐和呼吸频率经配对t检验比较P值均>0.20,差异没有统计学意义,提示抗纤溶治疗对这类患者肝肾功能和呼吸频率影响没有差异。结论:APL合并DIC患者,在存在明显纤溶亢进的条件下,抗纤溶治疗对这类患者脏器功能的影响并不明显。

Objective： To evaluate the effect of antifibrinolytic therapy on organ function of acute promyelocytic leukemia patients with DIC.Methods： 21 cases of acute promyelocytic leukemia with DIC who met the test standard were given all-trans-retinoic A acid（ATRA） for inducing differentiation therapy,at the same time,for antifibrinolytic therapy,0.9% NS 250ml ＋ aminomethylbenzoic acid 3.0g ivgtt qd were given.After one week,the effects of antifibrinolytic therapy on liver function,renal function,and respiratory rate were observed.Results： Before and after the antifibrinolytic therapy,the ALT,total bilirubin,serum creatinine,and respiratory rate of acute promyelocytic leukemia patients with DIC had no significant difference（P0.20）.Conclusion： When the condition of the significant hyperfibrinolysis existed,antifibrinolytic therapy has no obvious effect on organ function of acute promyelocytic leukemia patients with DIC.