多孔PLGA微球的应用研究进展

Research progress on the application of porous PLGA microspheres

多孔PLGA微球是一种新型的药物载体,安全无毒可生物降解,其多孔结构使其具有密度低、表面积大、表面渗透能力强等特点。同时多孔PLGA微球载药能力强,可包载亲、疏水性药物及多肽蛋白质类生物大分子药物,在药物的靶向输送、控制释放、组织再生与修复等方面研究越来越广泛。本文综述了多孔PLGA微球的制备方法及其在生物医药领域的应用,并对其发展前景进行展望。

Porous PLGA microsphere is a safe,non-toxic and biodegradable drug carrier,which possesses the characteristics of low density,large surface area,and high penetration capability due to its porous structure.Meanwhile,the porous microsphere has strong drug loading capacity so as to pack hydrophilic,hydrophobic drugs and biological macromolecular drugs.Now,this technology is widely applied in the areas of drug targeting,controlled release,as well as tissue regeneration and repair.This paper reviews the preparation methods of porous PLGA microsphere and its application in biological field.