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趋化因子MCP-1、MIP-lα、RANTES与自身免疫性疾病 被引量：5

Progress on MCP-1,MIP-lα and RANTES in autoimmune diseases(Review)
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摘要 趋化因子是一组复杂的小分子量分泌蛋白超家族。自身免疫性疾病的发病机制目前还尚未明了,近年来研究显示在广泛的炎症和自身免疫性疾病中已经观察到上调或下调趋化因子和趋化因子受体的表达,能够影响疾病的易感性、发展和严重性。本文对趋化因子的概况、MCP-1、MIP-lα、RANTES结构与生物学功能以及三者在自身免疫性疾病中的作用作一综述。 Chemokines are a family of small molecular weight secretary proteins. The pathogenesis of autoimmune diseases is still unclear. Recent studies have shown that up-regulated or down-regulated expression of chemokines and chemokine receptors were involved in the susceptibility, development and severity of a wide range of inflammatory and autoimmune diseases. The structural characteristics and biological functions of MCP-1, MIP-1a and RANTES in the pathogenesis of autoimmune diseases were summarized in this paper.
作者 张佩莲 邓丹琪
机构地区 昆明医科大学第二附属医院皮肤性病/风湿科
出处 《皮肤病与性病》 2012年第4期204-207,共4页 Dermatology and Venereology
关键词 趋化因子 单核细胞趋化蛋白-1( MCP-1) 巨噬细胞炎性蛋白-lα(MIP-lα) 调节活化正常T细胞表达与分泌的趋化因子(RANTES) 自身免疫性疾病 Chemokine MCP-1 MIP-1a RANTES Autoimmune diseases
分类号 R363.21 [医药卫生—病理学] R593.2 [医药卫生—内科学]
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参考文献26

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二级参考文献32

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皮肤病与性病
2012年 第4期

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