摘要
纳米晶体混悬给药系统可有效解决难溶性药物递药的问题,然而液体纳米晶体给药系统的物理稳定性差。固体纳米晶体给药系统作为液态纳米晶体混悬给药系统的一种改良技术,可克服液体纳米晶体混悬系统热动力学不稳定的现象,同时方便患者携带和使用,临床顺应性好,是实现纳米晶体混悬给药系统稳定化的理想选择。本文主要综述了固体纳米晶体给药系统的纳米化与固体化构建方法的研究进展,期望为该递药系统的发展提供借鉴与思考。
Nanocrystal suspensions drug delivery system is used to solve the delivery difficulty of poorly soluble drug. However, the physical stability of liquid nanocrystal suspensions is very bad. Solid nanocrystal delivery system as a novel technology, can improve the thermokinetics stability of nanocrystal suspensions and have good clinical compliance, which can achieve stabilization of nanocrystal suspension systems as an ideal delivery system. In this paper, we reviewed the research progress of nanotechnology and solidification technology of solid nanocrystal suspension delivery system, which will give the new mirrors and thoughts on the development of solid nanocrystal delivery system.
出处
《药学学报》
CAS
CSCD
北大核心
2012年第9期1120-1127,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81102821)
教育部留学归国人员创新基金资助项目(20101561)
北京市自然科学基金资助项目(7122176)
江西省卫生厅中医药科研项目(2011A134)
江西中医学院重点学科青年基金资助项目(2009zdxk015)
关键词
固体纳米晶体给药系统
纳米化
固体化
solid nanocrystal delivery system
nanotechnology
solidification technology
