龙力胶囊对环磷酰胺的增效减毒作用

Synergistic and attenuation effects of Longli capsule on cyclophosphamide

目的:探讨龙力胶囊(Longli capsule,LLC)对环磷酰胺(cyclophosphamide,CTX)的增效减毒作用。方法:以S180荷瘤小鼠为模型。实验分为荷瘤模型组、LLC组、CTX组、CTX+LLC组,另设正常对照组,连续给药10 d。观察各组小鼠抑瘤率和毒性反应;检测各组小鼠体质量、肿瘤质量、外周血白细胞数、骨髓有核细胞数、脾指数和胸腺指数;检测小鼠腹腔巨噬细胞吞噬能力,分析LLC对CTX的增效减毒作用。结果:CTX+LLC组小鼠体质量增加量明显高于CTX单药组。CTX,LLC和CTX+LLC均可抑制S180荷瘤小鼠移植瘤的生长,其抑瘤率分别为45.10%、36.12%和60.28%,LLC可明显增强CTX抑制肿瘤生长的作用(P<0.05)。与CTX组比较,LLC组及LLC+CTX组外周血白细胞数、骨髓有核细胞数、脾指数、胸腺指数、以及腹腔巨噬细胞吞噬能力均明显增高。结论:LLC对CTX具有一定的增效减毒作用。

Objective：To investigate the synergistic and attenuation effects of Longli capsule （LLC） on S180 sar-coma xenografted mice with cyelophosphamide. Methods：Mouse model of transplanted sarcoma S180 was used in this study. The tumor inhibition rate and the toxicity of cyclopbosphamide were observed. The body weight of mice, tumor weight, count of white blood cells, count of bone marrow nucleate cells, spleen index and thymus index were meas-ured. The phagocytotic function of macrophages was studied by observing phagocytotization of peritonea macrophages. Results：The increase of body weight of mice in LLC combined with cyclophosphamide （CTX） group was higher than that in CTX group （ P 〈 0.05 ）. CTX, LLC and LLC combined with CTX could inhibit the tumor growth, and the tumor inhibition rates were 45.10% ,36.12% and 60.28% , respectively. LLC remarkably enhanced the ability of CTX to inhibit the growth of sarcoma （ P 〈 0.05 ）. Compared with CTX group, the count of white blood cells and bone marrow nucleate cells, spleen index,thymus index and phagocytic activity of peritoneal macrophage were elevated in all LLC and CTX combination groups （ P 〈0. 05 ）. Conclusion ： LLC has synergism and attenuation effects on CTX. These re-sults suggest that LLC, as a biochemical modulator to enhance the therapeutic effects, is useful in cancer chemothera-py.