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miRNA对乳腺癌耐药的调控机制 被引量：4

The regulation of microRNA on breast cancer resistance and it's mechanisms
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摘要 microRNA(miRNA)作为乳腺癌耐药相关的分子标志物及治疗靶点,可能在药物代谢酶、乳腺癌干细胞、单核苷酸多态性等方面调控乳腺癌化疗敏感性。靶向调节miRNA的异常表达,恢复其正常的调控功能,可能是治疗乳腺癌的新策略。 MicroRNA（ miRNA）, as the important biomarker of drug resistance and therapeutic targets for breast cancer, can regulate the drug metabolizing enzymes, breast cancer stem cell（BCSC）, single nucleotide polymor-phism （SNP） and so on. It may be a totally new strategy for breast cancer by correcting the abnormal expression of miRNA and regaining the normal regulation in the tumor cell.
作者 吴韬 李艳琳 何苗 魏敏杰
机构地区 中国医科大学药学院药理学教研室
出处 《现代肿瘤医学》 CAS 2012年第9期1959-1962,共4页 Journal of Modern Oncology
基金 国家自然科学基金(编号:30973559 81173092 81102472) 沈阳市科技计划项目(编号:F11-264-1-19)
关键词 微小RNA 乳腺肿瘤 抗药性 肿瘤干细胞 多态性 单核苷酸 miRNA breast neoplasms drug resistance neoplastic stem cells polymorphisrn single nucleotide
分类号 R737.9 [医药卫生—肿瘤]
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参考文献28

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现代肿瘤医学
2012年 第9期

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