胃癌组织中IGF-1R及HER-2的表达及意义

Expressions of IGF-1R and HER-2 in human gastric carcinoma tissues and its clinical significance

目的探讨胃癌组织中HER-2及IGF-1R的表达及意义。方法免疫组化法检测80例胃癌组织中IGF-1R及HER-2的表达,同时分析二者的表达与胃癌患者的临床病理特征的关系。结果 HER-2与IGF-1R在胃癌中的表达分别为23.8%、83.8%;在正常胃黏膜组织中的阳性率分别为10.0%及20.0%,差异有统计学意义(P<0.05);二者表达与淋巴结转移及肿瘤浸润深度相关;另外IGF-1R的表达还与肿瘤分化程度相关。HER-2与IGF-1R在胃癌组织中的蛋白表达水平呈正相关(P=0.001,r=0.362);二者均阳性表达的胃癌患者预后较差。结论 IGF-1R及HER-2蛋白在胃癌中的表达与侵袭和转移相关,对预后判断有重要价值。

Objective To study the expression and significance of HER-2 and IGF-1 R proteins in gastric cancer. Methods Expressions of HER-2 and IGF-I R in 80 gastric cancer tissue samples were detected with immunohistochemical staining, and correlation of their expression with the clinicopathologic characteristics of gastric carcinoma were analyzed. Results The positive rate of HER-2 and IGF-1R expressions in tumor tissues were 23.8% and 83.8% ,significantly higher than that of 10. 0% and 20. 0% in tumor-free tissues,respectively（P 〈0. 05）. Correlation were found between expression levels of HER-2 and IGF-1R and lymph node metastasis, depth of tumor invasion, expression levels of IGF-1R were correlated with differentia- tion of tumor. A positive correlation was observed between the expression of HER-2 and IGF-1R（P =0. 001, r = 0. 362）. Poor prognosis was correlated with positive expression of beth HER-2 and IGF-1R. Conclusions The Results suggest that the expression of HER-2 and IGF-1R is correlated with the invaslveness and metastasis of human gastric carcinomas. Both can be used as an indicator for predicting the prognosis of gastrie cancel＇.