复方斑蝥胶囊对食管癌放疗增敏作用的研究

A study on Fufang Banmao Jiaonang in increasing the radiotherapy sensitivity of esophageal carcinoma

目的探讨复方斑蝥胶囊对食管癌放射治疗的增敏作用。方法回顾性分析75例食管癌患者行放射治疗及复方斑蝥胶囊联合放疗的治疗效果,结合患者的临床症状、食管造影、CT检查,纤维胃镜及病理确诊。其中45例采取单纯放射治疗(对照组),以6/15 MV X线常规外照射,每次1.8～2Gy,每周5次,照射总剂量为60～70Gy。30例患者行放疗+复方斑蝥胶囊治疗(观察组),放疗方案同对照组,放疗同时给予复方斑蝥胶囊,每次0.75g,每天2次。结果观察组较对照组放疗增敏比为1.61(40Gy时)和1.23(60～70Gy时),观察组治疗后的CR、PR分别为30%和63.3%,对照组治疗后的CR、PR分别为11.1%和55.6%,两组比较差异有统计学意义(P<0.05)。观察组能显著改善患者的卡氏评分,较对照组可显著减少放射性骨髓抑制的发生(P=0.01)。结论复方斑蝥胶囊对食管癌的放射治疗具有增敏作用,其联合放疗治疗食管癌较单纯放疗能更显著地缩小肿瘤组织,提高生活质量。同时可减缓放射性骨髓抑制。

Objective To evaluate the effect of increasing radiotherapy sensitivity to esophagus car- cinoma patients by Fufang Banmao Jiaonang. Methods Review analyzes 75 esophagus cancers, confirma- tion of which are obtained by clinical symptom, the oesophagus x-ray examination, CT, gastroscopy and pa- thology,45 cases of these patients （control group） are treated with 6/15MV-X by conformal radiotheropy technique of 1.8-2 Gy/time,5 times/week, the total dose are 60-70Gy. The others （ observation group） are managed by radiotherapy combined with Fufang Banmao Jiaonang, 0. 75g / time, bid. Results sensitiza- tion enhancement ratios （SERs） of Fufang Banmao Jiaonang are 1.61 and 1.23 at the time of 40Gy and 60- 70Gy respectively. CR, PR and NR of observation group are 30% , 63.3% and 6. 67% , significantly high- er than which of control group, comparing with control group, observation group significantly improves pa- tients＇ KPS score and decreases the incidence rate of bone marrow suppression. Conclusions Fufang Ban- mao Jiaonang can increase radiotherapy sensitivity of esophagus cancers. Combining with radiotherapy, it can significantly reduce the tumor tissue, improve the patients＇ quality of life and reduce the incidence rate of bone marrow suppression by radiotherapy.