期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗细胞凋亡因子DAD1的研究进展 被引量：5

下载PDF
导出
摘要 抗细胞凋亡因子(defender against cell death 1,DAD1)是定位于内质网膜上的寡糖基转移酶(OST)的一个亚基,它维持OST复合物的结构完整性,并参与对蛋白质的N-糖基化修饰。该基因最早从对温度敏感的仓鼠肾源性细胞株(tsBN7)的突变株中克隆,并发现具有抑制凋亡的功能。大量研究显示,DAD1基因表达于不同物种中,是高度保守的基因,其除了抗凋亡作用,还显示出促进细胞增殖方面的新作用。本文主要介绍DAD1的结构和功能研究进展,展望DAD1的研究前景和发展方向。
作者 杨舒雅 史娟 马斌芳 赵洁 金晓航
机构地区 第四军医大学人体解剖与组织胚胎学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2012年第4期315-318,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(31071012 30871004) 第四军医大学学员课外科研项目(2010)资助课题
关键词 DAD1 凋亡 寡糖基转移酶 精子发生
分类号 R34 [医药卫生—基础医学] Q71 [生物学—分子生物学]
  • 相关文献

参考文献14

  • 1Nakashima T, Sekiguchi T, Kuraoka A, et al. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol Cell Biol, 1993, 13 : 6367 -6374.
  • 2Kelleher DJ, Gilmore R. DAD1, the defender against apop- totic cell death, is a subunit of the mammalian oligosac- charyhransferase. Proc Natl Acad Sci USA, 1997, 94 : 4994 - 4999.
  • 3Roboti P, High S. The oligosaccharyltransferase subunits 0ST48, DAD1 and KCP2 function as ubiquitous and selec-tive modulators of mammalian N-glycosylation. J Cell Sci, 2012 ,doi: 10. 1242/jcs. 103952.
  • 4Marchler-Bauer A, Anderson JB, Chitsaz F, et al. CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Res, 2009, 37 : D205 -D210.
  • 5Moharikar S, DSouza JS, Rao BJ. A homologue of the de- fender against the apoptotic death gene ( dadl ) in UV-ex- posed Chlamydomonas cells is downregulated with the onset of programmed cell death. J Biosci, 2007, 32 : 261 - 270.
  • 6Mohhathong S, Senapin S, lation of defender against yellow head virus ( YHV ) Penaeus monodon. Fish Klinbunga S, et al. Down-regu- apoptotic death ( DAD1 ) after challenge in black tiger shrimp Shellfish Immunol, 2008, 24 :173 - 179.
  • 7Thomas CA, Grant SG, Pflug BR, et al. (Z) -1,1-Dichloro- 2-(4-methoxyphenyl)-3- phenylcyclopropane induces con- centration-dependent growth inhibition, apoptosis, and coor- dinates regulation of apoptotic genes in TRAMP cells. Urol Oncol, 2008, 26 : 378-385.
  • 8True L, Coleman I, Hawley S, et al. A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci USA, 2006, 103 : 10991 - 10996.
  • 9Chopra M, Dharmarajan AM, Meiss G, et al. Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetra- chlorodibenzo-p-dioxin. Toxicol Sci, 2009, 111 : 49 - 63.
  • 10Yoon J, Kim ES, Lee S J, et al. Apoptosis-related mRNA expression profiles of ovarian cancer cell lines following cis- platin treatment. J Gynecol Oncol, 2010, 21 : 255 -261.

同被引文献74

  • 1贾志蓉,李丹,吕应堂.拟南芥AtDAD 1超量表达植株对H_2O_2抗性的研究[J].武汉植物学研究,2004,22(5):373-379. 被引量：5
  • 2王利,吴信忠.青石斑鱼抗细胞凋亡因子DAD1的克隆及表达特征分析[J].海洋学报,2007,29(3):125-130. 被引量：4
  • 3Kerr J F, Wyllie A H, Currie A R. Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics[ J ]. British Jour- nal of Cancer, 1972,26(4) :239-257.
  • 4Wyllie A H, Morris R G, Smith A L,et al. Chormatin cleavage in apoptosis:association with condensed chromatin morphology and dependence on macromolecular synthesis [ J ]. The Journal of Pathology, 1984,142 (1) :67-77.
  • 5Fuchs Y, Steller H. Programmed cell death in animal devepment and disease[ J]. Cell ,2011,147 (4) :742-758.
  • 6Joza N, Susin S A, Daugas E, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death [ J ]. Nature,2001,410 ( 6828 ) :549-554.
  • 7Scorrano L, Oakes S A, Opferman J T, et al. Bax and bak regulation of endoplasmic reticulum Ca2+ :a control point for apoptosis [ J ]. Science, 2003,300(5616) :135-139.
  • 8Liu Y, Schiff M, Czymmek K, et al. Autophagy regulates programmed cell death during the plant innate immune response [ J ]. Cell, 2005,121 (4) :567-571.
  • 9Sperandio S, Poksay K S, Schilling B, et al. Identification of new modulators and protein alterations in non-apoptosis programmed cell death [ J ]. Journal of Cellular Biochemistry ,2010,111 (6) : 1401-1412.
  • 10Trobacher C P, Senatore A, Holley C, et al. Induction of a ricinosomal-prorease and programmed cell death in tomato endosperm by gibberellic acid[ J]. Planta,2013,237 ( 3 ) :665-679.

引证文献5

二级引证文献7

生理科学进展
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部