糖尿病患者肿瘤标志物分析

Tumor markers in patients with diabetes mellitus

目的探讨糖代谢紊乱时肿瘤标志物分泌特点及相关因素。方法 2型糖尿病患者(T2DM)154例(糖尿病组),健康者147例(对照组),采用罗氏E170全自动免疫分析仪检测肿瘤标志物,采用罗氏C8000检测空腹血糖(FBG),根据血糖水平将糖尿病患者血清分为A(3.4≤FBG≤8.0mmol/L),B(8.0<FBG≤14.0mmol/L),C(FBG>14.0mmol/L)三组,进行肿瘤标志物与空腹血糖的相关性分析。结果糖尿病组CEA,CA199,CA125,CA153,CYFRA21-1,NSE中位数均明显高于对照组(2.23μg/L vs 1.57μg/L,11.80U/ml vs 8.12U/ml,10.67U/ml vs 7.97U/ml,10.30U/ml vs 7.4U/ml,2.58ng/ml vs 1.53ng/ml,10.56ng/ml vs 9.5ng/ml,P<0.01);糖尿病相关肿瘤标志物异常率为CYFRA21-1>CEA>CA199>CA125>CA153>NSE,CA199随空腹血糖升高而升高;糖尿病组CEA,CA125与性别相关,男性CEA大于女性(2.45μg/L vs 1.64μg/L,P<0.01),女性CA125大于男性(11.67U/ml vs 10.17U/ml,P<0.05),CA199与年龄呈正相关r=0.161(P<0.05)。结论糖尿病会导致多项肿瘤标志物升高。

Objective To study the secretion characteristics of tumor markers in patients with disturbance of carbohydrate metabolism and the correlation between tumor markers and fasting blood glucose（FBG） level. Methods One hundred and fifty-four patients with type 2 diabetes mellitus （T2DM） served as a diabetic group and 147 healthy subjects served as a control group in this study. Their tumor markers were detected with Roche El70 hol-automatic immune analyzer and their FBG level was measured with Roche C8000 automatic biochemical analyzer. The patients were divided into group A, group B and group C according to their FBG level（3.4 ≤ FBG ≤ 8.0mmol/L）, 8.0〈FBG ≤ 14.0mmol/L, FBG〉14.0mmol/L）. Correlation between tumor markers and FBG level was analyzed. Results The mean CEA, CA199, CA125, CA153, CYFRA21-1 and NSE were significantly higher in T2DM group than in control group （2.23 μ g/L vs 1.57 μ g/L, 11.80U/ml vs 8.12U/ml, 10.67U/ml vs 7.97U/ml, 10.30U/ml vs 7.4U/ml, 2.58ng/ml vs 1.53 ng/ml, 10.56ng/ml vs 9.5ng/ml, P〈0.01）. The abnormal rate of DM-related tumor markers was CYFRA21- I〉CEA〉CA199〉CA125〉CA153〉NSE. The CA199 level increased with the elevated FBG level. The CEA and CA125 levels were correlated with gender in T2DM group. The CEA level was significantly higher in males than in females （2.45μ g/L vs 1.64 μ g/L, P〈0.01） while the CA125 level was significantly higher in females than in males （11.67U/ml vs 10.17U/ml, P〈0.05）. The CA199 level was positively correlated with age （r=-0.161, P〈0.05）. Conclusion DM can increase the level of many tumor markers.