口服补镁对实验性老年2型糖尿病大鼠胰岛素受体表达水平的影响

Effect of oral magnesium supplement on expression of insulin receptor in elderly rats with type 2 diabetes mellitus

目的观察口服补镁对老年2型糖尿病大鼠胰岛素受体表达水平的影响。方法将老年2型糖尿病大鼠模型分为不同剂量的口服补镁组,测定大鼠空腹血糖、血清胰岛素及胰腺和骨骼肌组织胰岛素受体表达水平。结果高剂量补镁组(2g/kg)胰腺中胰岛素受体表达水平(MOD值)由0.331±0.003提高至0.342±0.002;骨骼肌组织胰岛素受体表达水平由0.345±0.003提高至0.355±0.002,差异均有统计学意义(P<0.05)。同时,高剂量补镁组空腹血糖由(16.85±0.76)mmol/L降至(15.49±0.57)mmol/L,而血清胰岛素水平由(20.35±0.52)μIU/ml降至(19.05±0.62)μIU/ml。结论口服补镁可显著提高老年2型糖尿病大鼠胰岛素受体表达水平,改善胰岛素敏感性。

Objective To observe the effect of oral magnesium supplement on expression of insulin receptor in elderly rats with type 2 diabetes mellitus （DM）. Methods Elderly rats with type 2 DM were divided into different oral magnesium dose supplement groups. Fasting glucose, serum insulin, and insulin receptor expression levels in pancreas and skeletal muscles were measured. Results The expression level of insulin receptor increased from 0.331 ± 0.003 to 0.342 ± 0.002 and from 0.345 ± 0.003 to 0.355 ± 0.002, respectively, while the fasting glucose and serum insulin levels decreased from 16.85± 0.76mmol/L to 15.49 ±0.57mmol/L and from 20.35 ±0.52 μIU/ml to 19.05 ± 0.62 μIU/ml, respectively, in pancreas and skeletal muscles of the high dose （2g/kg） oral magnesium dose group（P〈0.05）. Conclusion Oral magnesium supplement can significantly increase the expression level of insulin receptor and imorove the insulin sensitivity in elderly rats with tyoe 2 DM.